PMID- 10517866
OWN - NLM
STAT- MEDLINE
DCOM- 19991223
LR  - 20061115
IS  - 0265-9247 (Print)
IS  - 0265-9247 (Linking)
VI  - 21
IP  - 11
DP  - 1999 Nov
TI  - The tetratricopeptide repeat: a structural motif mediating protein-protein
      interactions.
PG  - 932-9
AB  - The tetratricopeptide repeat (TPR) motif is a protein-protein interaction module 
      found in multiple copies in a number of functionally different proteins that
      facilitates specific interactions with a partner protein(s). Three-dimensional
      structural data have shown that a TPR motif contains two antiparallel
      alpha-helices such that tandem arrays of TPR motifs generate a right-handed
      helical structure with an amphipathic channel that might accommodate the
      complementary region of a target protein. Most TPR-containing proteins are
      associated with multiprotein complexes, and there is extensive evidence
      indicating that TPR motifs are important to the functioning of chaperone,
      cell-cycle, transcription, and protein transport complexes. The TPR motif may
      represent an ancient protein-protein interaction module that has been recruited
      by different proteins and adapted for specific functions. BioEssays
      1999;21:932-939.
CI  - Copyright 1999 John Wiley & Sons, Inc.
FAU - Blatch, G L
AU  - Blatch GL
AD  - Protein-Structure-Function Research Programme, Department of Cell Biology,
      University of the Witwatersrand, Johannesburg, South Africa.
FAU - Lassle, M
AU  - Lassle M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Bioessays
JT  - BioEssays : news and reviews in molecular, cellular and developmental biology
JID - 8510851
RN  - 0 (Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Humans
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - Protein Binding
MH  - Protein Structure, Secondary
MH  - Protein Structure, Tertiary
MH  - Proteins/*chemistry
MH  - *Repetitive Sequences, Amino Acid
MH  - Sequence Alignment
RF  - 86
EDAT- 1999/10/12 00:00
MHDA- 1999/10/12 00:01
CRDT- 1999/10/12 00:00
PHST- 1999/10/12 00:00 [pubmed]
PHST- 1999/10/12 00:01 [medline]
PHST- 1999/10/12 00:00 [entrez]
AID - 10.1002/(SICI)1521-1878(199911)21:11<932::AID-BIES5>3.0.CO;2-N [pii]
AID - 10.1002/(SICI)1521-1878(199911)21:11<932::AID-BIES5>3.0.CO;2-N [doi]
PST - ppublish
SO  - Bioessays. 1999 Nov;21(11):932-9. doi:
      10.1002/(SICI)1521-1878(199911)21:11<932::AID-BIES5>3.0.CO;2-N.