PMID- 10514386
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 0002-9440 (Linking)
VI  - 155
IP  - 4
DP  - 1999 Oct
TI  - Immunohistochemical analysis of uroplakins, urothelial specific proteins, in
      ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the 
      female genital tract.
PG  - 1047-50
AB  - Uroplakins are the characteristic integral membrane proteins in terminally
      differentiated, superficial urothelial asymmetric unit membrane. Brenner tumors
      of the ovary and Walthard cell nests of Fallopian tubes have been considered to
      represent urothelial differentiation in the female genital tract, but no
      definitive differentiation marker has been demonstrated supporting such a
      conclusion. An immunohistochemical analysis was performed to assess the
      expression of uroplakins in these lesions as well as in various benign and
      neoplastic lesions and normal tissues of the female genital tract. Focal
      expression of uroplakins was observed on the luminal surface of ovarian Brenner
      tumor cells forming microcysts in all 5 cases examined. In contrast, uroplakins
      were slightly expressed in only 1 of 12 cases of Walthard cell nests, even in the
      presence of microcyst formation. Uroplakins were not expressed in other benign or
      malignant lesions or normal tissues of the female genital tract. These results
      support the hypothesis that the Brenner tumor and possibly Walthard cell nests
      represent urothelial (transitional cell) differentiation.
FAU - Ogawa, K
AU  - Ogawa K
AD  - Department of Pathology, University of Nebraska Medical Center, Omaha, Nebraska, 
      USA.
FAU - Johansson, S L
AU  - Johansson SL
FAU - Cohen, S M
AU  - Cohen SM
LA  - eng
GR  - CA36727/CA/NCI NIH HHS/United States
GR  - R01 DK039753/DK/NIDDK NIH HHS/United States
GR  - P30 CA036727/CA/NCI NIH HHS/United States
GR  - CA32513/CA/NCI NIH HHS/United States
GR  - DK39753/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (UPK1A protein, human)
RN  - 0 (UPK1B protein, human)
RN  - 0 (UPK2 protein, human)
RN  - 0 (Uroplakin II)
RN  - 0 (Uroplakin III)
RN  - 0 (Uroplakin Ia)
RN  - 0 (Uroplakin Ib)
SB  - AIM
SB  - IM
MH  - Brenner Tumor/*metabolism
MH  - Cell Differentiation
MH  - Cell Membrane/metabolism
MH  - Cysts/metabolism
MH  - Cytoplasm/metabolism
MH  - Female
MH  - Genital Neoplasms, Female/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Membrane Glycoproteins/*biosynthesis
MH  - Membrane Proteins/biosynthesis
MH  - Ovarian Neoplasms/*metabolism
MH  - Urinary Bladder/metabolism
MH  - Uroplakin II
MH  - Uroplakin III
MH  - Uroplakin Ia
MH  - Uroplakin Ib
PMC - PMC1867018
EDAT- 1999/10/09 00:00
MHDA- 1999/10/09 00:01
CRDT- 1999/10/09 00:00
PHST- 1999/10/09 00:00 [pubmed]
PHST- 1999/10/09 00:01 [medline]
PHST- 1999/10/09 00:00 [entrez]
AID - S0002-9440(10)65206-6 [pii]
AID - 10.1016/S0002-9440(10)65206-6 [doi]
PST - ppublish
SO  - Am J Pathol. 1999 Oct;155(4):1047-50. doi: 10.1016/S0002-9440(10)65206-6.