PMID- 10512762
OWN - NLM
STAT- MEDLINE
DCOM- 19991123
LR  - 20061115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 263
IP  - 3
DP  - 1999 Oct 5
TI  - Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show
      testis-specific gene expression.
PG  - 810-5
AB  - Metalloproteinase-disintegrins (ADAMs) are type 1 transmembrane proteins that
      contain a unique domain structure including a zinc-binding metalloproteinase
      domain. We have isolated cDNAs encoding two novel members of this family, ADAM29 
      and ADAM30 which show testis-specific expression. Three forms of ADAM29 were
      found that encode proteins of 820, 786 and 767 amino acids. All of the amino acid
      differences are located in the cytoplasmic domain. Two forms of ADAM30 were
      isolated that encode proteins of 790 and 781 amino acids, with the difference in 
      the coding region occurring in the cytoplasmic domain. ADAM29 and ADAM30 map to
      human chromosome 4q34 and 1p11-13, respectively. An ancestral analysis of all
      known mammalian ADAMs indicates that the zinc-binding motif in the catalytic
      domain arose once in a common ancestor and was subsequently lost by those members
      lacking this motif.
CI  - Copyright 1999 Academic Press.
FAU - Cerretti, D P
AU  - Cerretti DP
AD  - Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA.
      cerretti@immunex.com
FAU - DuBose, R F
AU  - DuBose RF
FAU - Black, R A
AU  - Black RA
FAU - Nelson, N
AU  - Nelson N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA, Complementary)
RN  - 0 (Disintegrins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Recombinant Proteins)
RN  - EC 3.4.24.- (ADAM Proteins)
RN  - EC 3.4.24.- (ADAM29 protein, human)
RN  - EC 3.4.24.- (ADAM30 protein, human)
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - ADAM Proteins
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Membrane/metabolism
MH  - *Chromosome Mapping
MH  - Chromosomes, Human
MH  - Cloning, Molecular
MH  - Cytoplasm/metabolism
MH  - *DNA, Complementary
MH  - Disintegrins/chemistry/*metabolism
MH  - Evolution, Molecular
MH  - Female
MH  - Gene Library
MH  - Humans
MH  - Male
MH  - Mammals
MH  - Membrane Proteins/genetics/isolation & purification
MH  - Metalloendopeptidases/chemistry/*genetics/isolation & purification
MH  - Mice
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Phylogeny
MH  - Recombinant Proteins/biosynthesis/chemistry/isolation & purification
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Testis/*metabolism
EDAT- 1999/10/08 00:00
MHDA- 1999/10/08 00:01
CRDT- 1999/10/08 00:00
PHST- 1999/10/08 00:00 [pubmed]
PHST- 1999/10/08 00:01 [medline]
PHST- 1999/10/08 00:00 [entrez]
AID - 10.1006/bbrc.1999.1322 [doi]
AID - S0006-291X(99)91322-0 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Oct 5;263(3):810-5. doi: 10.1006/bbrc.1999.1322.