PMID- 10512749
OWN - NLM
STAT- MEDLINE
DCOM- 19991123
LR  - 20081121
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 263
IP  - 3
DP  - 1999 Oct 5
TI  - Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain
      encoding two apparently unrelated proteins.
PG  - 737-42
AB  - Three related cDNAs (C184L, C184M, and C184S) were isolated from a developing
      mouse brain cDNA library. C184S is the 5'-end portion and C184M is the 3'-end
      portion, respectively, of C184L. C184S and C184M have open reading frames of 199 
      amino acids (ORF1) and 189 amino acids (ORF2), respectively; C184L has both ORF1 
      and ORF2 (dicistronic structure), but seems to translate only ORF1. Southern blot
      analysis suggests that all of the three related mRNAs are transcribed from the
      same single gene. The intervening region of C184L cDNA between ORF1 and ORF2
      contained a promoter sequence for C184M mRNA, which is transcribed from the
      corresponding genomic sequence. Very recently, a cDNA encoding human homologue of
      ORF1 (human autoantigen p27) and a cDNA encoding a different mouse isoform of
      ORF2 (mammary tumor virus receptor) were reported. Our results indicate that the 
      mRNAs encoding these apparently unrelated proteins are transcribed within an
      adjacent or overlapping area on the genome, suggesting the same origin of the two
      transcription units.
CI  - Copyright 1999 Academic Press.
FAU - Sakuma-Takagi, M
AU  - Sakuma-Takagi M
AD  - Institute of Life Science, Soka University, Hachioji, Tokyo, 192-8577, Japan.
FAU - Tohyama, Y
AU  - Tohyama Y
FAU - Kasama-Yoshida, H
AU  - Kasama-Yoshida H
FAU - Sakagami, H
AU  - Sakagami H
FAU - Kondo, H
AU  - Kondo H
FAU - Kurihara, T
AU  - Kurihara T
LA  - eng
SI  - GENBANK/AB012726
SI  - GENBANK/AB012727
SI  - GENBANK/AB012865
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Autoantigens)
RN  - 0 (DNA, Complementary)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Aging/*genetics
MH  - Amino Acid Sequence
MH  - Animals
MH  - Autoantigens/chemistry/*genetics
MH  - Base Sequence
MH  - Brain/embryology/growth & development/*metabolism
MH  - DNA, Complementary/*genetics
MH  - Embryonic and Fetal Development/*genetics
MH  - *Gene Expression Regulation, Developmental
MH  - *Gene Library
MH  - Humans
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/chemistry/*genetics
MH  - Open Reading Frames
MH  - Organ Specificity
MH  - Promoter Regions, Genetic
MH  - Protein Biosynthesis
MH  - Protein Isoforms/chemistry/genetics
MH  - RNA, Messenger/genetics
MH  - Restriction Mapping
MH  - Transcription, Genetic
EDAT- 1999/10/08 00:00
MHDA- 1999/10/08 00:01
CRDT- 1999/10/08 00:00
PHST- 1999/10/08 00:00 [pubmed]
PHST- 1999/10/08 00:01 [medline]
PHST- 1999/10/08 00:00 [entrez]
AID - 10.1006/bbrc.1999.1462 [doi]
AID - S0006-291X(99)91462-6 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Oct 5;263(3):737-42. doi:
      10.1006/bbrc.1999.1462.