PMID- 10512743
OWN - NLM
STAT- MEDLINE
DCOM- 19991123
LR  - 20111003
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 263
IP  - 3
DP  - 1999 Oct 5
TI  - IL1HY1: A novel interleukin-1 receptor antagonist gene.
PG  - 702-6
AB  - Interleukin-1 is a potent mediator of inflammation, involved in regulating a wide
      variety of physiological and cellular events. We have identified and
      characterized a novel member of the human interleukin-1 gene family (IL1HY1). The
      encoded protein demonstrates significant amino acid homology to the receptor
      antagonist (IL-1ra) at 52%. The gene was mapped to the long arm of chromosome 2, 
      in close proximity to the IL-1 locus. IL1HY1 message is tightly regulated being
      most predominantly expressed in the skin, but also detected in the spleen, brain 
      leukocyte, and macrophage cell types. Furthermore, the message can be induced in 
      THP-1 cells by phorbol ester (PMA) and lipopolysaccharide (LPS) treatment.
CI  - Copyright 1999 Academic Press.
FAU - Mulero, J J
AU  - Mulero JJ
AD  - Functional Genomics Department, Immunology Group, Hyseq Inc., 670 Almanor Avenue,
      Sunnyvale, California 94086, USA.
FAU - Pace, A M
AU  - Pace AM
FAU - Nelken, S T
AU  - Nelken ST
FAU - Loeb, D B
AU  - Loeb DB
FAU - Correa, T R
AU  - Correa TR
FAU - Drmanac, R
AU  - Drmanac R
FAU - Ford, J E
AU  - Ford JE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (IL1RN protein, human)
RN  - 0 (IL36RN protein, human)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukins)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Sialoglycoproteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Brain/immunology
MH  - Cell Line
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 2
MH  - Fetus
MH  - Gene Amplification
MH  - Gene Library
MH  - Humans
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - *Interleukins
MH  - Leukocytes/immunology
MH  - Macrophages/immunology
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Organ Specificity
MH  - Proteins/chemistry/*genetics
MH  - RNA, Messenger/genetics
MH  - Receptors, Interleukin-1/*antagonists & inhibitors
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Sialoglycoproteins/chemistry/genetics
MH  - Skin/embryology/*immunology
MH  - Spleen/immunology
MH  - Transcription, Genetic
EDAT- 1999/10/08 00:00
MHDA- 1999/10/08 00:01
CRDT- 1999/10/08 00:00
PHST- 1999/10/08 00:00 [pubmed]
PHST- 1999/10/08 00:01 [medline]
PHST- 1999/10/08 00:00 [entrez]
AID - 10.1006/bbrc.1999.1440 [doi]
AID - S0006-291X(99)91440-7 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Oct 5;263(3):702-6. doi: 10.1006/bbrc.1999.1440.