PMID- 10512742
OWN - NLM
STAT- MEDLINE
DCOM- 19991123
LR  - 20061115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 263
IP  - 3
DP  - 1999 Oct 5
TI  - Tissue distribution of the human soluble guanylate cyclases.
PG  - 696-701
AB  - Soluble guanylate cyclase (sGC) is an important component of the NO signaling
      pathway. Human sGC isoforms alpha(1), alpha(2), and beta(1) show differential
      mRNA tissue distributions. alpha(1) and beta(1) are expressed in most tissues;
      however, the alpha(2) isoform shows a more restricted expression pattern with
      high levels in brain, placenta, spleen, and uterus only. Both alpha subunits
      exist as multiple transcripts whereas beta(1) exists as a single message. This
      study reports for the first time the tissue distribution of human sGC message and
      demonstrates that sGC isoforms are nonuniformly expressed which may be useful if 
      the enzyme is to be exploited as a therapeutic target.
CI  - Copyright 1999 Academic Press.
FAU - Budworth, J
AU  - Budworth J
AD  - Wolfson Institute for Biomedical Research, University College London, 1 Wakefield
      Street, London, WC1N 1PJ, United Kingdom. j.budworth@ucl.ac.uk
FAU - Meillerais, S
AU  - Meillerais S
FAU - Charles, I
AU  - Charles I
FAU - Powell, K
AU  - Powell K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Isoenzymes)
RN  - 0 (RNA, Messenger)
RN  - EC 4.6.1.2 (Guanylate Cyclase)
SB  - IM
MH  - Blotting, Northern
MH  - Brain/enzymology
MH  - Cytoplasm/enzymology
MH  - Female
MH  - *Gene Expression Regulation, Enzymologic
MH  - Guanylate Cyclase/analysis/*genetics
MH  - Humans
MH  - Isoenzymes/analysis/genetics
MH  - Male
MH  - Organ Specificity
MH  - Placenta/enzymology
MH  - Pregnancy
MH  - RNA, Messenger/genetics
MH  - Spleen/enzymology
MH  - *Transcription, Genetic
MH  - Uterus/enzymology
EDAT- 1999/10/08 00:00
MHDA- 1999/10/08 00:01
CRDT- 1999/10/08 00:00
PHST- 1999/10/08 00:00 [pubmed]
PHST- 1999/10/08 00:01 [medline]
PHST- 1999/10/08 00:00 [entrez]
AID - 10.1006/bbrc.1999.1444 [doi]
AID - S0006-291X(99)91444-4 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Oct 5;263(3):696-701. doi:
      10.1006/bbrc.1999.1444.