PMID- 10512676
OWN - NLM
STAT- MEDLINE
DCOM- 19991109
LR  - 20061115
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 61
IP  - 1
DP  - 1999 Oct 1
TI  - An olfactory receptor gene is located in the extended human beta-globin gene
      cluster and is expressed in erythroid cells.
PG  - 15-23
AB  - An olfactory receptor gene was identified near the 3' breakpoint of a naturally
      occurring deletion (HPFH-1) in the human beta-globin gene cluster on chromosome
      11p15.5. The gene encodes an amino acid sequence that is 40 to 51% identical to
      that of a set of olfactory receptors that have only recently been identified as a
      distinct family of receptors. There are two orthologous genes in the mouse that
      encode amino acid sequences that are 73 and 71% identical, respectively, to that 
      encoded by the human gene. This olfactory receptor gene is expressed at the RNA
      level in human and murine erythroid cells at all stages of development. This
      aberrant expression is probably due to the location of the gene in the
      transcriptionally active chromatin domain of the extended beta-globin gene
      cluster in erythroid cells.
CI  - Copyright 1999 Academic Press.
FAU - Feingold, E A
AU  - Feingold EA
AD  - Clinical Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, 
      Maryland 20892, USA.
FAU - Penny, L A
AU  - Penny LA
FAU - Nienhuis, A W
AU  - Nienhuis AW
FAU - Forget, B G
AU  - Forget BG
LA  - eng
SI  - GENBANK/AF154673
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (OR52A1 protein, human)
RN  - 0 (Receptors, Odorant)
RN  - 9004-22-2 (Globins)
RN  - 9007-49-2 (DNA)
RN  - 9034-63-3 (Fetal Hemoglobin)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cell Line
MH  - *Chromosomes, Human, Pair 11
MH  - DNA
MH  - Fetal Hemoglobin
MH  - Gene Deletion
MH  - Gene Expression
MH  - Globins/*genetics
MH  - Hemoglobinopathies/genetics
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Receptors, Odorant/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Ribonucleases
MH  - Sequence Analysis, DNA
MH  - Tumor Cells, Cultured
EDAT- 1999/10/08 00:00
MHDA- 1999/10/08 00:01
CRDT- 1999/10/08 00:00
PHST- 1999/10/08 00:00 [pubmed]
PHST- 1999/10/08 00:01 [medline]
PHST- 1999/10/08 00:00 [entrez]
AID - 10.1006/geno.1999.5935 [doi]
AID - S0888-7543(99)95935-9 [pii]
PST - ppublish
SO  - Genomics. 1999 Oct 1;61(1):15-23. doi: 10.1006/geno.1999.5935.