PMID- 10512192
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20181201
IS  - 0145-5680 (Print)
IS  - 0145-5680 (Linking)
VI  - 45
IP  - 5
DP  - 1999 Jul
TI  - The role of the notochord for epaxial myotome formation in the mouse.
PG  - 601-16
AB  - The vertebrate somite is the source of all trunk skeletal muscles. Myogenesis in 
      avian embryos is thought to depend on signals from notochord and neural tube for 
      the epaxial muscles, and signals from lateral mesoderm and surface ectoderm for
      the hypaxial muscles. However, this hypothesis has to be tested because in mouse 
      mutants lacking a notochord the presence of a fused myotome beneath the neural
      tube has been reported. We have compared the expression pattern of myogenic
      markers and markers for the hypaxial muscle precursors in the mutants Brachyury
      curtailed, truncate, Danforth's short tail and Pintail. In regions lacking
      notochord and sclerotome, we found small, ventrally located domains of Myf5 and
      MyoD expression, concomitant with ventrally expanded Pax3 signals and upregulated
      expression of the hypaxial marker Lbx1, suggesting that only the hypaxial program
      is active. We therefore hypothesise that in mammals, as in birds, the formation
      of the epaxial musculature depends on the presence of notochord derived signals.
FAU - Dietrich, S
AU  - Dietrich S
AD  - King's College London, Department of Craniofacial Development, UK.
      s.dietrich@umds.ac.uk
FAU - Schubert, F R
AU  - Schubert FR
FAU - Gruss, P
AU  - Gruss P
FAU - Lumsden, A
AU  - Lumsden A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (Fetal Proteins)
RN  - 0 (Genetic Markers)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Lbx1h protein, mouse)
RN  - 0 (Muscle Proteins)
RN  - 0 (Myf5 protein, mouse)
RN  - 0 (MyoD Protein)
RN  - 0 (Myogenic Regulatory Factor 5)
RN  - 0 (PAX3 Transcription Factor)
RN  - 0 (PAX6 Transcription Factor)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (Pax6 protein, mouse)
RN  - 0 (Repressor Proteins)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 138016-91-8 (Pax3 protein, mouse)
RN  - 142661-96-9 (PAX1 transcription factor)
RN  - EQ43SC3GDB (Brachyury protein)
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/genetics
MH  - Eye Proteins
MH  - Female
MH  - *Fetal Proteins
MH  - *Gene Expression Regulation, Developmental
MH  - Genetic Markers
MH  - *Homeodomain Proteins
MH  - In Situ Hybridization
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Muscle Proteins/genetics
MH  - Muscle, Skeletal/*embryology
MH  - *Mutation
MH  - MyoD Protein/genetics
MH  - Myogenic Regulatory Factor 5
MH  - Notochord/*physiology
MH  - PAX3 Transcription Factor
MH  - PAX6 Transcription Factor
MH  - Paired Box Transcription Factors
MH  - Repressor Proteins
MH  - T-Box Domain Proteins/genetics
MH  - *Trans-Activators
MH  - Transcription Factors/genetics
EDAT- 1999/10/08 00:00
MHDA- 1999/10/08 00:01
CRDT- 1999/10/08 00:00
PHST- 1999/10/08 00:00 [pubmed]
PHST- 1999/10/08 00:01 [medline]
PHST- 1999/10/08 00:00 [entrez]
PST - ppublish
SO  - Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):601-16.