PMID- 10508511
OWN - NLM
STAT- MEDLINE
DCOM- 19991019
LR  - 20161124
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 23
IP  - 2
DP  - 1999 Oct
TI  - Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.
PG  - 159-65
AB  - The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that
      confers susceptibility to Friend virus-induced erythroleukaemia in mice. We
      mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the
      stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the 
      most abundant form of Stk in Fv2-sensitive (Fv2ss) erythroid cells, was not
      expressed in Fv2 resistant (Fv2rr) cells. Enforced expression of Sf-stk conferred
      susceptibility to Friend disease, whereas targeted disruption of Ron caused
      resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally
      expressed, truncated form of Stk confers susceptibility to Friend virus-induced
      erythroleukaemia.
FAU - Persons, D A
AU  - Persons DA
AD  - Department of Experimental Hematology, St. Jude Children's Research Hospital,
      Memphis, Tennessee 38105, USA.
FAU - Paulson, R F
AU  - Paulson RF
FAU - Loyd, M R
AU  - Loyd MR
FAU - Herley, M T
AU  - Herley MT
FAU - Bodner, S M
AU  - Bodner SM
FAU - Bernstein, A
AU  - Bernstein A
FAU - Correll, P H
AU  - Correll PH
FAU - Ney, P A
AU  - Ney PA
LA  - eng
GR  - R01 CA084214-02/CA/NCI NIH HHS/United States
GR  - R01 CA084214-03/CA/NCI NIH HHS/United States
GR  - R01 CA084214-05/CA/NCI NIH HHS/United States
GR  - P30 CA21765/CA/NCI NIH HHS/United States
GR  - R01 CA084214-04/CA/NCI NIH HHS/United States
GR  - R01 CA084214/CA/NCI NIH HHS/United States
GR  - R01 CA084214-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (Protein Isoforms)
RN  - 0 (Receptors, Cell Surface)
RN  - EC 2.7.10.1 (RON protein)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
CIN - Nat Genet. 1999 Oct;23(2):128-30. PMID: 10508499
MH  - 3T3 Cells
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Contig Mapping
MH  - *Friend murine leukemia virus
MH  - Gene Expression
MH  - Genetic Predisposition to Disease
MH  - Leukemia, Erythroblastic, Acute/*genetics
MH  - Mice
MH  - Mice, Inbred AKR
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Inbred CBA
MH  - Mice, Inbred NZB
MH  - Mice, Inbred Strains
MH  - Molecular Sequence Data
MH  - Muridae
MH  - Protein Isoforms/genetics
MH  - Receptor Protein-Tyrosine Kinases/*genetics
MH  - Receptors, Cell Surface/*genetics
MH  - Retroviridae Infections/genetics
MH  - Species Specificity
MH  - Spleen/cytology/metabolism/pathology
MH  - Tumor Virus Infections/genetics
EDAT- 1999/10/03 09:00
MHDA- 2001/03/23 10:01
CRDT- 1999/10/03 09:00
PHST- 1999/10/03 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/10/03 09:00 [entrez]
AID - 10.1038/13787 [doi]
PST - ppublish
SO  - Nat Genet. 1999 Oct;23(2):159-65. doi: 10.1038/13787.