PMID- 10508243
OWN - NLM
STAT- MEDLINE
DCOM- 19991026
LR  - 20180424
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 29
IP  - 9
DP  - 1999 Sep
TI  - The murine beta-chemokine TARC is expressed by subsets of dendritic cells and
      attracts primed CD4+ T cells.
PG  - 2684-94
AB  - To investigate specific properties of dendritic cells (DC) which are not shared
      by other antigen-presenting cells, we compared gene expression patterns of mouse 
      DC and macrophages by differential mRNA display. One of the cDNA identified coded
      for a murine homolog of the human beta-chemokine, thymus and activation-regulated
      chemokine (TARC). The gene is expressed in a subset of bone marrow-derived DC and
      is up-regulated after lipopolysaccharide (LPS) stimulation. In vivo, murine TARC 
      (mTARC) is constitutively expressed by thymic DC, lymphnode DC and CD11c+ cells
      in the lung. No expression was detected in bone marrow-derived macrophages and
      LPS-activated B cells. Recombinant mTARC has no chemoattractant activity on naive
      peripheral CD4+ T cells. In contrast, mTARC induced migration of primed
      ovalbumin-specific CD4+ T cells with a preference for Th2 cells during the early 
      phase of the T cell response. These observations suggest that mTARC directs
      migration of antigen-experienced T helper cells to DC in lymphoid as well as in
      non-lymphoid organs.
FAU - Lieberam, I
AU  - Lieberam I
AD  - Institute for Genetics, University of Cologne, Cologne, Germany.
      lieberam@uni-koeln.de
FAU - Forster, I
AU  - Forster I
LA  - eng
SI  - GENBANK/AJ242587
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (CCL17 protein, human)
RN  - 0 (Ccl17 protein, mouse)
RN  - 0 (Chemokine CCL17)
RN  - 0 (Chemokines, CC)
RN  - 0 (DNA, Complementary)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Bone Marrow Cells/chemistry/immunology
MH  - CD4-Positive T-Lymphocytes/drug effects/*immunology/metabolism
MH  - Chemokine CCL17
MH  - Chemokines, CC/*biosynthesis/genetics/immunology
MH  - Cloning, Molecular
MH  - DNA, Complementary/isolation & purification
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Lymphocyte Activation
MH  - Macrophages/chemistry/immunology
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Transgenic
MH  - Molecular Sequence Data
MH  - Sequence Homology, Amino Acid
EDAT- 1999/10/03 00:00
MHDA- 1999/10/03 00:01
CRDT- 1999/10/03 00:00
PHST- 1999/10/03 00:00 [pubmed]
PHST- 1999/10/03 00:01 [medline]
PHST- 1999/10/03 00:00 [entrez]
AID - 10.1002/(SICI)1521-4141(199909)29:09<2684::AID-IMMU2684>3.0.CO;2-Y [doi]
PST - ppublish
SO  - Eur J Immunol. 1999 Sep;29(9):2684-94. doi:
      10.1002/(SICI)1521-4141(199909)29:09<2684::AID-IMMU2684>3.0.CO;2-Y.