PMID- 10508235
OWN - NLM
STAT- MEDLINE
DCOM- 19991101
LR  - 20171213
IS  - 0031-9333 (Print)
IS  - 0031-9333 (Linking)
VI  - 79
IP  - 4
DP  - 1999 Oct
TI  - Mechanism of action and in vivo role of platelet-derived growth factor.
PG  - 1283-316
AB  - Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue
      cells and certain other cell types. It is a dimeric molecule consisting of
      disulfide-bonded, structurally similar A- and B-polypeptide chains, which combine
      to homo- and heterodimers. The PDGF isoforms exert their cellular effects by
      binding to and activating two structurally related protein tyrosine kinase
      receptors, denoted the alpha-receptor and the beta-receptor. Activation of PDGF
      receptors leads to stimulation of cell growth, but also to changes in cell shape 
      and motility; PDGF induces reorganization of the actin filament system and
      stimulates chemotaxis, i.e., a directed cell movement toward a gradient of PDGF. 
      In vivo, PDGF has important roles during the embryonic development as well as
      during wound healing. Moreover, overactivity of PDGF has been implicated in
      several pathological conditions. The sis oncogene of simian sarcoma virus (SSV)
      is related to the B-chain of PDGF, and SSV transformation involves autocrine
      stimulation by a PDGF-like molecule. Similarly, overproduction of PDGF may be
      involved in autocrine and paracrine growth stimulation of human tumors.
      Overactivity of PDGF has, in addition, been implicated in nonmalignant conditions
      characterized by an increased cell proliferation, such as atherosclerosis and
      fibrotic conditions. This review discusses structural and functional properties
      of PDGF and PDGF receptors, the mechanism whereby PDGF exerts its cellular
      effects, and the role of PDGF in normal and diseased tissues.
FAU - Heldin, C H
AU  - Heldin CH
AD  - Ludwig Institute for Cancer Research, Biomedical Center, and Department of
      Pathology, University Hospital, Uppsala, Sweden. C-H.Heldin@LICR.uu.se
FAU - Westermark, B
AU  - Westermark B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Physiol Rev
JT  - Physiological reviews
JID - 0231714
RN  - 0 (Platelet-Derived Growth Factor)
RN  - EC 2.7.10.1 (Receptors, Platelet-Derived Growth Factor)
SB  - IM
MH  - Animals
MH  - Disease
MH  - Embryonic and Fetal Development
MH  - Humans
MH  - Platelet-Derived Growth Factor/genetics/pharmacology/*physiology
MH  - Receptors, Platelet-Derived Growth Factor/chemistry/genetics/*physiology
MH  - Signal Transduction
RF  - 516
EDAT- 1999/10/03 00:00
MHDA- 1999/10/03 00:01
CRDT- 1999/10/03 00:00
PHST- 1999/10/03 00:00 [pubmed]
PHST- 1999/10/03 00:01 [medline]
PHST- 1999/10/03 00:00 [entrez]
AID - 10.1152/physrev.1999.79.4.1283 [doi]
PST - ppublish
SO  - Physiol Rev. 1999 Oct;79(4):1283-316. doi: 10.1152/physrev.1999.79.4.1283.