PMID- 10508233
OWN - NLM
STAT- MEDLINE
DCOM- 19991101
LR  - 20171213
IS  - 0031-9333 (Print)
IS  - 0031-9333 (Linking)
VI  - 79
IP  - 4
DP  - 1999 Oct
TI  - Prostanoid receptors: structures, properties, and functions.
PG  - 1193-226
AB  - Prostanoids are the cyclooxygenase metabolites of arachidonic acid and include
      prostaglandin (PG) D(2), PGE(2), PGF(2alpha), PGI(2), and thromboxne A(2). They
      are synthesized and released upon cell stimulation and act on cells in the
      vicinity of their synthesis to exert their actions. Receptors mediating the
      actions of prostanoids were recently identified and cloned. They are G
      protein-coupled receptors with seven transmembrane domains. There are eight types
      and subtypes of prostanoid receptors that are encoded by different genes but as a
      whole constitute a subfamily in the superfamily of the rhodopsin-type receptors. 
      Each of the receptors was expressed in cultured cells, and its ligand-binding
      properties and signal transduction pathways were characterized. Moreover, domains
      and amino acid residues conferring the specificities of ligand binding and signal
      transduction are being clarified. Information also is accumulating as to the
      distribution of these receptors in the body. It is also becoming clear for some
      types of receptors how expression of their genes is regulated. Furthermore, the
      gene for each of the eight types of prostanoid receptor has been disrupted, and
      mice deficient in each type of receptor are being examined to identify and assess
      the roles played by each receptor under various physiological and
      pathophysiological conditions. In this article, we summarize these findings and
      attempt to give an overview of the current status of research on the prostanoid
      receptors.
FAU - Narumiya, S
AU  - Narumiya S
AD  - Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan.
FAU - Sugimoto, Y
AU  - Sugimoto Y
FAU - Ushikubi, F
AU  - Ushikubi F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Physiol Rev
JT  - Physiological reviews
JID - 0231714
RN  - 0 (Prostaglandins)
RN  - 0 (Receptors, Prostaglandin)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - GTP-Binding Proteins/physiology
MH  - Gene Expression Regulation
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Prostaglandins/metabolism
MH  - Receptors, Prostaglandin/*chemistry/genetics/*physiology
MH  - Signal Transduction
RF  - 254
EDAT- 1999/10/03 00:00
MHDA- 1999/10/03 00:01
CRDT- 1999/10/03 00:00
PHST- 1999/10/03 00:00 [pubmed]
PHST- 1999/10/03 00:01 [medline]
PHST- 1999/10/03 00:00 [entrez]
AID - 10.1152/physrev.1999.79.4.1193 [doi]
PST - ppublish
SO  - Physiol Rev. 1999 Oct;79(4):1193-226. doi: 10.1152/physrev.1999.79.4.1193.