PMID- 10506756
OWN - NLM
STAT- MEDLINE
DCOM- 19991108
LR  - 20191024
IS  - 0899-1987 (Print)
IS  - 0899-1987 (Linking)
VI  - 26
IP  - 2
DP  - 1999 Oct
TI  - cDNA isolation, expression, and chromosomal localization of the mouse pcph
      proto-oncogene.
PG  - 130-6
AB  - We report here the isolation and characterization of a cDNA from mouse thymus
      encoding the murine homolog of the protein product of the Syrian hamster Pcph
      proto-oncogene. The single open reading frame identified in the cDNA sequence
      encoded a protein predicted to have 428 amino acids, which shared 93.7% amino
      acid identity with the Syrian hamster Pcph within the first 412 residues but had 
      a shorter, highly dissimilar C-terminus. Northern and western analyses revealed
      that Pcph mRNA and protein were widely distributed in mouse embryo and adult
      tissues, with the highest expression in adults detected in kidney and liver. The 
      mouse Pcph proto-oncogene was mapped by linkage analysis to within 3.3+/-2.3 cM
      of Pkch-rs1 on chromosome 12. These data should prove valuable in designing
      studies to define the cellular function of the Pcph proto-oncogene.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Recio, J A
AU  - Recio JA
AD  - Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine,
      Georgetown University Medical Center, Washington, District of Columbia, 20007,
      USA.
FAU - Zambrano, N
AU  - Zambrano N
FAU - de La Pena, L
AU  - de La Pena L
FAU - Powers, C
AU  - Powers C
FAU - Siwarski, D
AU  - Siwarski D
FAU - Huppi, K
AU  - Huppi K
FAU - Notario, V
AU  - Notario V
LA  - eng
GR  - CA 64472/CA/NCI NIH HHS/United States
GR  - P30 CA 51008/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Carcinog
JT  - Molecular carcinogenesis
JID - 8811105
RN  - 0 (DNA, Complementary)
RN  - 0 (Oncogene Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - *Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA, Complementary/metabolism
MH  - Gene Library
MH  - Genetic Linkage
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Oncogene Proteins/*genetics/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 1999/10/03 09:00
MHDA- 2000/05/08 09:00
CRDT- 1999/10/03 09:00
PHST- 1999/10/03 09:00 [pubmed]
PHST- 2000/05/08 09:00 [medline]
PHST- 1999/10/03 09:00 [entrez]
AID - 10.1002/(SICI)1098-2744(199910)26:2<130::AID-MC7>3.0.CO;2-N [pii]
AID - 10.1002/(sici)1098-2744(199910)26:2<130::aid-mc7>3.0.co;2-n [doi]
PST - ppublish
SO  - Mol Carcinog. 1999 Oct;26(2):130-6. doi:
      10.1002/(sici)1098-2744(199910)26:2<130::aid-mc7>3.0.co;2-n.