PMID- 10506710
OWN - NLM
STAT- MEDLINE
DCOM- 19991018
LR  - 20051116
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 86
IP  - 7
DP  - 1999 Oct 1
TI  - Chromosome rearrangement at 17q25 and xp11.2 in alveolar soft-part sarcoma: A
      case report and review of the literature.
PG  - 1246-50
AB  - BACKGROUND: Despite the characteristic histopathologic appearance of alveolar
      soft-part sarcoma (ASPS), its histogenesis remains unclear, and cytogenetic
      analysis of ASPS is limited to eight cases so far because of the extreme rarity
      of this disease. METHODS: The authors document a cytogenetic study of a primary
      case of ASPS in which a modern spectral karyotyping technique was used. RESULTS: 
      A standard cytogenetic analysis of the primary tumor cells with G-banding
      revealed 46,XY, add(17)(q25) in 23 of 25 metaphases analyzed. This structural
      rearrangement of chromosome 17, involving band q25, was also present in 5 of 8
      ASPS cases in the literature. Moreover, with the spectral karyotyping technique, 
      the additional part of the long arm of chromosome 17 in the current case was
      found to originate from chromosome X, resulting in a final tumor karyotype of 46,
      XY, add(17)(q25).ish der(17)t(X;17) (p11.2;q25)(wcpX+). CONCLUSIONS: This case
      report documents a clonal chromosome abnormality of der(17)t(X;17)(p11.2;q25) in 
      ASPS. The results of the current study indicate that further molecular analyses
      focused on 17q25 and Xp11.2 are of interest and could help to elucidate the
      pathogenesis of ASPS.
CI  - Copyright 1999 American Cancer Society.
FAU - Joyama, S
AU  - Joyama S
AD  - Department of Orthopedic Surgery, Osaka Medical Center for Cancer and
      Cardiovascular Diseases, Osaka, Japan.
FAU - Ueda, T
AU  - Ueda T
FAU - Shimizu, K
AU  - Shimizu K
FAU - Kudawara, I
AU  - Kudawara I
FAU - Mano, M
AU  - Mano M
FAU - Funai, H
AU  - Funai H
FAU - Takemura, K
AU  - Takemura K
FAU - Yoshikawa, H
AU  - Yoshikawa H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - AIM
SB  - IM
MH  - Child
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 17
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - Sarcoma, Alveolar Soft Part/*genetics/pathology
MH  - Soft Tissue Neoplasms/*genetics/pathology
MH  - *X Chromosome
RF  - 24
EDAT- 1999/10/03 00:00
MHDA- 1999/10/03 00:01
CRDT- 1999/10/03 00:00
PHST- 1999/10/03 00:00 [pubmed]
PHST- 1999/10/03 00:01 [medline]
PHST- 1999/10/03 00:00 [entrez]
AID - 10.1002/(SICI)1097-0142(19991001)86:7<1246::AID-CNCR20>3.0.CO;2-4 [pii]
PST - ppublish
SO  - Cancer. 1999 Oct 1;86(7):1246-50.