PMID- 10506207
OWN - NLM
STAT- MEDLINE
DCOM- 19991109
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 41
DP  - 1999 Oct 8
TI  - Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is
      restricted to glandular epithelium and differentiated keratinocytes.
PG  - 29439-52
AB  - Epithelial cell differentiation is tightly controlled by distinct sets of
      transcription factors that regulate the expression of stage-specific genes. We
      recently isolated the first epithelium-specific Ets transcription factor (ESE-1).
      Here we describe the characterization of ESE-2, a second epithelium-restricted
      ESE-1-related Ets factor. Like ESE-1, ESE-2 is induced during keratinocyte
      differentiation. However, whereas ESE-1 is expressed in the majority of
      epithelial cell types, ESE-2 expression is restricted to differentiated
      keratinocytes and glandular epithelium such as salivary gland, prostate, mammary 
      gland, and kidney. In contrast to ESE-1, full-length ESE-2 binds poorly to DNA
      due to the presence of a negative regulatory domain at the amino terminus.
      Furthermore, although ESE-1 and the amino-terminally deleted ESE-2 bind with
      similar affinity to the canonical E74 Ets site, ESE-2 and ESE-1 differ strikingly
      in their relative affinity toward binding sites in the c-MET and PSMA promoters. 
      Similarly, ESE-1 and ESE-2 drastically differ in their ability to transactivate
      epithelium-specific promoters. Thus, ESE-2, but not ESE-1, transactivates the
      parotid gland-specific PSP promoter and the prostate-specific PSA promoter. In
      contrast, ESE-1 transactivates the keratinocyte-specific SPRR2A promoter Ets site
      and the prostate-specific PSMA promoter significantly better than ESE-2. Our
      results demonstrate the existence of a unique class of related
      epithelium-specific Ets factors with distinct functions in epithelial cell gene
      regulation.
FAU - Oettgen, P
AU  - Oettgen P
AD  - New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical
      Center, Boston, Massachusetts 02115, USA.
FAU - Kas, K
AU  - Kas K
FAU - Dube, A
AU  - Dube A
FAU - Gu, X
AU  - Gu X
FAU - Grall, F
AU  - Grall F
FAU - Thamrongsak, U
AU  - Thamrongsak U
FAU - Akbarali, Y
AU  - Akbarali Y
FAU - Finger, E
AU  - Finger E
FAU - Boltax, J
AU  - Boltax J
FAU - Endress, G
AU  - Endress G
FAU - Munger, K
AU  - Munger K
FAU - Kunsch, C
AU  - Kunsch C
FAU - Libermann, T A
AU  - Libermann TA
LA  - eng
SI  - GENBANK/AF115402
SI  - GENBANK/AF115403
GR  - K08/CA 71429/CA/NCI NIH HHS/United States
GR  - P01/CA 72009/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (BPIFA2 protein, human)
RN  - 0 (Cornified Envelope Proline-Rich Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (ELF3 protein, human)
RN  - 0 (ELF5 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Protein Precursors)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (RNA, Messenger)
RN  - 0 (SPRR2A protein, human)
RN  - 0 (Salivary Proteins and Peptides)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Alternative Splicing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Cell Differentiation
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Cornified Envelope Proline-Rich Proteins
MH  - DNA-Binding Proteins
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Keratinocytes
MH  - Membrane Proteins/genetics
MH  - Molecular Sequence Data
MH  - Parotid Gland
MH  - Promoter Regions, Genetic
MH  - Prostate-Specific Antigen/genetics
MH  - Protein Precursors/genetics
MH  - *Proto-Oncogene Proteins
MH  - Proto-Oncogene Proteins c-ets
MH  - RNA, Messenger/metabolism
MH  - Regulatory Sequences, Nucleic Acid
MH  - Salivary Proteins and Peptides/genetics
MH  - Sequence Alignment
MH  - Trans-Activators/chemistry
MH  - Transcription Factors/chemistry/*genetics
MH  - Transcriptional Activation/*genetics
EDAT- 1999/10/03 00:00
MHDA- 1999/10/03 00:01
CRDT- 1999/10/03 00:00
PHST- 1999/10/03 00:00 [pubmed]
PHST- 1999/10/03 00:01 [medline]
PHST- 1999/10/03 00:00 [entrez]
AID - 10.1074/jbc.274.41.29439 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Oct 8;274(41):29439-52. doi: 10.1074/jbc.274.41.29439.