PMID- 10502109
OWN - NLM
STAT- MEDLINE
DCOM- 19991217
LR  - 20191103
IS  - 0949-944X (Print)
IS  - 0949-944X (Linking)
VI  - 209
IP  - 9
DP  - 1999 Sep
TI  - Mouse Dach, a homologue of Drosophila dachshund, is expressed in the developing
      retina, brain and limbs.
PG  - 526-36
AB  - The Drosophila genes eyeless, eyes absent, sine oculis, and dachshund cooperate
      as key regulators of retinal cell-fate determination. Homologues of eyeless
      (Pax6), eyes absent (Eya1-2), and sine oculis (Six3) have been identified and are
      expressed in the developing vertebrate eye. We have cloned and characterized the 
      structure and expression of mouse Dach, a homologue of Drosophila dachshund.
      Sequence analysis reveals the presence of two motifs, DD1 and DD2, which may be
      involved in the function of Dach/Dachshund as gene regulatory factors. In
      addition, DD1 shares sequence similarity to N-terminal sequences of Ski and SnoN,
      which are involved in cellular transformation and differentiation. Mouse and
      human Dach/DACH were localized to chromosome 14E1 and 13q21.3-22, respectively,
      by fluorescence in situ hybridization. Finally, in situ hybridization analysis
      demonstrated that Dach is expressed in similar tissues to those observed in
      Drosophila, including the embryonic nervous system, sensory organs, and limbs.
      The finding of Dach expression in the eye completes the list of vertebrate
      homologues of eyeless, eyes absent, sine oculis, and dachshund which as a group
      may function to control cell-fate determination in the vertebrate eye.
FAU - Davis, R J
AU  - Davis RJ
AD  - Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston,
      TX 77030, USA.
FAU - Shen, W
AU  - Shen W
FAU - Heanue, T A
AU  - Heanue TA
FAU - Mardon, G
AU  - Mardon G
LA  - eng
SI  - GENBANK/AF129510
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Dev Genes Evol
JT  - Development genes and evolution
JID - 9613264
RN  - 0 (Drosophila Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (dac protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/*embryology
MH  - *Chromosome Mapping
MH  - Cloning, Molecular
MH  - Crosses, Genetic
MH  - Drosophila/embryology/genetics
MH  - *Drosophila Proteins
MH  - Embryonic and Fetal Development
MH  - *Gene Expression Regulation, Developmental
MH  - Humans
MH  - Limb Buds/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL/genetics
MH  - Molecular Sequence Data
MH  - Muridae/*genetics
MH  - Nuclear Proteins/chemistry/*genetics
MH  - Recombinant Proteins/biosynthesis/chemistry
MH  - Retina/*embryology
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
EDAT- 1999/09/29 00:00
MHDA- 1999/09/29 00:01
CRDT- 1999/09/29 00:00
PHST- 1999/09/29 00:00 [pubmed]
PHST- 1999/09/29 00:01 [medline]
PHST- 1999/09/29 00:00 [entrez]
AID - 92090526.427 [pii]
AID - 10.1007/s004270050285 [doi]
PST - ppublish
SO  - Dev Genes Evol. 1999 Sep;209(9):526-36. doi: 10.1007/s004270050285.