PMID- 10500098
OWN - NLM
STAT- MEDLINE
DCOM- 19991025
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 13
IP  - 18
DP  - 1999 Sep 15
TI  - RANK is essential for osteoclast and lymph node development.
PG  - 2412-24
AB  - The physiological role of the TNF receptor (TNFR) family member, RANK, was
      investigated by generating RANK-deficient mice. RANK(-/-) mice were characterized
      by profound osteopetrosis resulting from an apparent block in osteoclast
      differentiation. RANK expression was not required for the commitment,
      differentiation, and functional maturation of macrophages and dendritic cells
      from their myeloid precursors but provided a necessary and specific signal for
      the differentiation of myeloid-derived osteoclasts. RANK(-/-) mice also exhibited
      a marked deficiency of B cells in the spleen. RANK(-/-) mice retained
      mucosal-associated lymphoid tissues including Peyer's patches but completely
      lacked all other peripheral lymph nodes, highlighting an additional major role
      for RANK in lymph node formation. These experiments reveal that RANK provides
      critical signals necessary for lymph node organogenesis and osteoclast
      differentiation.
FAU - Dougall, W C
AU  - Dougall WC
AD  - Immunex Corporation, Seattle, Washington 98101 USA. wdougall@immunex.com
FAU - Glaccum, M
AU  - Glaccum M
FAU - Charrier, K
AU  - Charrier K
FAU - Rohrbach, K
AU  - Rohrbach K
FAU - Brasel, K
AU  - Brasel K
FAU - De Smedt, T
AU  - De Smedt T
FAU - Daro, E
AU  - Daro E
FAU - Smith, J
AU  - Smith J
FAU - Tometsko, M E
AU  - Tometsko ME
FAU - Maliszewski, C R
AU  - Maliszewski CR
FAU - Armstrong, A
AU  - Armstrong A
FAU - Shen, V
AU  - Shen V
FAU - Bain, S
AU  - Bain S
FAU - Cosman, D
AU  - Cosman D
FAU - Anderson, D
AU  - Anderson D
FAU - Morrissey, P J
AU  - Morrissey PJ
FAU - Peschon, J J
AU  - Peschon JJ
FAU - Schuh, J
AU  - Schuh J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RANK Ligand)
RN  - 0 (Receptor Activator of Nuclear Factor-kappa B)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tnfrsf11a protein, mouse)
RN  - 0 (Tnfsf11 protein, mouse)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/physiology
MH  - Bone Resorption/metabolism
MH  - Bone and Bones/diagnostic imaging
MH  - *Carrier Proteins
MH  - Dendritic Cells/physiology
MH  - Flow Cytometry
MH  - Gene Targeting
MH  - Hematopoiesis, Extramedullary/genetics
MH  - Hematopoietic Stem Cells/cytology
MH  - Lymph Nodes/*embryology
MH  - Macrophage Colony-Stimulating Factor/metabolism
MH  - Macrophages/physiology
MH  - *Membrane Glycoproteins
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Osteoclasts/*physiology
MH  - Osteopetrosis/diagnostic imaging/metabolism
MH  - Peyer's Patches/anatomy & histology
MH  - Phenotype
MH  - RANK Ligand
MH  - Radiography
MH  - Receptor Activator of Nuclear Factor-kappa B
MH  - Receptors, Tumor Necrosis Factor/*genetics/metabolism/*physiology
MH  - Spleen/anatomy & histology/embryology
PMC - PMC317030
EDAT- 1999/09/29 00:00
MHDA- 1999/09/29 00:01
CRDT- 1999/09/29 00:00
PHST- 1999/09/29 00:00 [pubmed]
PHST- 1999/09/29 00:01 [medline]
PHST- 1999/09/29 00:00 [entrez]
AID - 10.1101/gad.13.18.2412 [doi]
PST - ppublish
SO  - Genes Dev. 1999 Sep 15;13(18):2412-24. doi: 10.1101/gad.13.18.2412.