PMID- 10499918
OWN - NLM
STAT- MEDLINE
DCOM- 19991019
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 190
IP  - 6
DP  - 1999 Sep 20
TI  - Identification and molecular cloning of p75/AIRM1, a novel member of the
      sialoadhesin family that functions as an inhibitory receptor in human natural
      killer cells.
PG  - 793-802
AB  - In this study, by the generation of a specific monoclonal antibody, we identified
      p75/AIRM1 (for adhesion inhibitory receptor molecule 1), a novel inhibitory
      receptor that is mostly confined to human natural killer cells. p75/AIRM1 is a
      75-kD glycoprotein that, upon sodium pervanadate treatment, becomes tyrosine
      phosphorylated and associates to src homology 2 domain-bearing protein tyrosine
      phosphatase (SHP)-1. The p75/AIRM1 gene is located on human chromosome 19 and
      encodes a novel member of the sialoadhesin family characterized by three
      immunoglobulin-like extracellular domains (one NH(2)-terminal V-type and two
      C2-type) and a classical immunoreceptor tyrosine-based inhibitory motif (ITIM) in
      the cytoplasmic portion. The highest amino acid sequence similarity has been
      found with the myeloid-specific CD33 molecule and the placental CD33L1 protein.
      Similar to other sialoadhesin molecules, p75/AIRM1 appears to mediate sialic
      acid-dependent ligand recognition.
FAU - Falco, M
AU  - Falco M
AD  - Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy.
FAU - Biassoni, R
AU  - Biassoni R
FAU - Bottino, C
AU  - Bottino C
FAU - Vitale, M
AU  - Vitale M
FAU - Sivori, S
AU  - Sivori S
FAU - Augugliaro, R
AU  - Augugliaro R
FAU - Moretta, L
AU  - Moretta L
FAU - Moretta, A
AU  - Moretta A
LA  - eng
SI  - GENBANK/AJ007395
SI  - GENBANK/AJ130710
SI  - GENBANK/AJ130711
SI  - GENBANK/AJ130712
SI  - GENBANK/AJ130713
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulin Variable Region)
RN  - 0 (Ligands)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (adhesion inhibitory receptor molecule 1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 19
MH  - Cloning, Molecular
MH  - Glycoproteins/genetics/immunology
MH  - Humans
MH  - Immunoglobulin Variable Region/genetics/immunology
MH  - Killer Cells, Natural/*immunology
MH  - Ligands
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - Receptors, Immunologic/*genetics/immunology
MH  - src Homology Domains
PMC - PMC2195632
EDAT- 1999/09/28 00:00
MHDA- 1999/09/28 00:01
CRDT- 1999/09/28 00:00
PHST- 1999/09/28 00:00 [pubmed]
PHST- 1999/09/28 00:01 [medline]
PHST- 1999/09/28 00:00 [entrez]
AID - 10.1084/jem.190.6.793 [doi]
PST - ppublish
SO  - J Exp Med. 1999 Sep 20;190(6):793-802. doi: 10.1084/jem.190.6.793.