PMID- 10499586
OWN - NLM
STAT- MEDLINE
DCOM- 19991014
LR  - 20091119
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 401
IP  - 6750
DP  - 1999 Sep 16
TI  - Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth
      morphogenesis.
PG  - 279-82
AB  - Pitx1 and Pitx2 are highly homologous, bicoid-related transcription factors.
      Pitx2 was initially identified as the gene responsible for the human Rieger
      syndrome, an autosomal dominant condition that causes developmental
      abnormalities. Pitx2 is asymmetrically expressed in the left lateral-plate
      mesoderm, and mutant mice with laterality defects show altered patterns of Pitx2 
      expression that correlate with changes in the visceral symmetry (situs). Ectopic 
      expression of Pitx2 in the right lateral-plate mesoderm alters looping of the
      heart and gut and reverses body rotation in chick and Xenopus embryos. Here we
      describe the phenotype of Pitx2 gene-deleted mice, characterized by defective
      body-wall closure, right pulmonary isomerism, altered cardiac position, arrest in
      turning and, subsequently, a block in the determination and proliferation events 
      of anterior pituitary gland and tooth organogenesis. Thus, Pitx2 is a
      transcription factor that encodes 'leftness' of the lung.
FAU - Lin, C R
AU  - Lin CR
AD  - Howard Hughes Medical Institute, Department and School of Medicine, University of
      California, San Diego, La Jolla 92093, USA.
FAU - Kioussi, C
AU  - Kioussi C
FAU - O'Connell, S
AU  - O'Connell S
FAU - Briata, P
AU  - Briata P
FAU - Szeto, D
AU  - Szeto D
FAU - Liu, F
AU  - Liu F
FAU - Izpisua-Belmonte, J C
AU  - Izpisua-Belmonte JC
FAU - Rosenfeld, M G
AU  - Rosenfeld MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (Receptors, Growth Factor)
RN  - 0 (Transcription Factors)
RN  - 0 (homeobox protein PITX1)
RN  - 0 (homeobox protein PITX3)
RN  - 184787-43-7 (homeobox protein PITX2)
RN  - EC 2.7.11.30 (Activin Receptors, Type II)
SB  - IM
MH  - Abnormalities, Multiple/embryology/genetics
MH  - Activin Receptors, Type II
MH  - Animals
MH  - Body Patterning/genetics/physiology
MH  - Cell Line
MH  - Chick Embryo
MH  - Chimera
MH  - Gene Deletion
MH  - Heart/*embryology
MH  - Heart Defects, Congenital/embryology/genetics
MH  - Homeodomain Proteins/genetics/*physiology
MH  - Lung/*embryology
MH  - *Nuclear Proteins
MH  - Paired Box Transcription Factors
MH  - Phenotype
MH  - Pituitary Gland/embryology
MH  - Receptors, Growth Factor/physiology
MH  - Tooth/*embryology
MH  - Transcription Factors/genetics/*physiology
MH  - Xenopus
EDAT- 1999/09/28 09:00
MHDA- 2001/03/23 10:01
CRDT- 1999/09/28 09:00
PHST- 1999/09/28 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/09/28 09:00 [entrez]
AID - 10.1038/45803 [doi]
PST - ppublish
SO  - Nature. 1999 Sep 16;401(6750):279-82. doi: 10.1038/45803.