PMID- 10498683
OWN - NLM
STAT- MEDLINE
DCOM- 19991119
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 126
IP  - 20
DP  - 1999 Oct
TI  - Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required 
      for germline cell division and oocyte differentiation.
PG  - 4477-88
AB  - Lissencephaly is a severe congenital brain malformation resulting from incomplete 
      neuronal migration. One causal gene, LIS1, is homologous to nudF, a gene required 
      for nuclear migration in A. nidulans. We have characterized the Drosophila 
      homolog of LIS1 (Lis1) and show that Lis1 is essential for fly development. 
      Analysis of ovarian Lis1 mutant clones demonstrates that Lis1 is required in the 
      germline for synchronized germline cell division, fusome integrity and oocyte 
      differentiation. Abnormal packaging of the cysts was observed in Lis1 mutant 
      clones. Our results indicate that LIS1 is important for cell division and 
      differentiation and the function of the membrane cytoskeleton. They support the 
      notion that LIS1 functions with the dynein complex to regulate nuclear migration 
      or cell migration.
FAU - Liu, Z
AU  - Liu Z
AD  - The Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers 
      University, Piscataway, New Jersey 08854-8020, USA.
FAU - Xie, T
AU  - Xie T
FAU - Steward, R
AU  - Steward R
LA  - eng
SI  - GENBANK/AF152419
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (DNA Primers)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Lis-1 protein, Drosophila)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Molecular Motor Proteins)
RN  - 0 (Proteins)
RN  - EC 3.1.1.47 (1-Alkyl-2-acetylglycerophosphocholine Esterase)
RN  - EC 3.1.1.47 (PAFAH1B1 protein, human)
RN  - EC 3.6.4.2 (Dyneins)
SB  - IM
MH  - 1-Alkyl-2-acetylglycerophosphocholine Esterase
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/*abnormalities
MH  - Cell Differentiation/genetics
MH  - Cell Division/genetics
MH  - Cell Movement/genetics
MH  - Cloning, Molecular
MH  - DNA Primers/genetics
MH  - Drosophila/cytology/*genetics/growth & development
MH  - Drosophila Proteins
MH  - Dyneins/genetics
MH  - Female
MH  - *Genes, Insect
MH  - Humans
MH  - *Microtubule-Associated Proteins
MH  - Molecular Motor Proteins/genetics
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Oocytes/*cytology/growth & development
MH  - Proteins/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
EDAT- 1999/09/28 00:00
MHDA- 1999/09/28 00:01
CRDT- 1999/09/28 00:00
PHST- 1999/09/28 00:00 [pubmed]
PHST- 1999/09/28 00:01 [medline]
PHST- 1999/09/28 00:00 [entrez]
AID - 10.1242/dev.126.20.4477 [doi]
PST - ppublish
SO  - Development. 1999 Oct;126(20):4477-88. doi: 10.1242/dev.126.20.4477.