PMID- 10498628
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20131121
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 94
IP  - 7
DP  - 1999 Oct 1
TI  - TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a
      specific receptor.
PG  - 2533-6
AB  - Chemokines regulate leukocytes trafficking in normal and inflammation conditions.
      Thymus-seeding progenitors are made in bone marrow and migrate to the thymus
      where they undergo their maturation to antigen-specific T cells. Immature T cells
      are in thymic cortex, while mature thymocytes are in medulla. Chemokines may be
      important for homing of thymus-seeding progenitors, and/or differential thymocyte
      localization in thymus. Here we report that GPR-9-6, now called CC chemokine
      receptor 9 (CCR9), is a receptor for thymus-expressed chemokine, TECK. Among a
      panel of chemokines tested, TECK specifically induced calcium flux in
      CCR9-expressing cell lines. We also showed that TECK efficaciously induced
      chemotaxis of immature CD4(+)CD8(+) double-positive, and mature CD4(+) and CD8(+)
      single-positive human thymocytes. Our data suggest that TECK/CCR9 interaction may
      play a pivotal role in T-cell migration in the thymus.
FAU - Youn, B S
AU  - Youn BS
AD  - Department of Microbiology, Walther Oncology Center, Indianapolis, IN, USA.
FAU - Kim, C H
AU  - Kim CH
FAU - Smith, F O
AU  - Smith FO
FAU - Broxmeyer, H E
AU  - Broxmeyer HE
LA  - eng
GR  - R01 DK53674/DK/NIDDK NIH HHS/United States
GR  - R01 HL56416/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (CC chemokine receptor 9)
RN  - 0 (CCL25 protein, human)
RN  - 0 (Chemokines, CC)
RN  - 0 (Receptors, CCR)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Recombinant Proteins)
RN  - SY7Q814VUP (Calcium)
SB  - AIM
SB  - IM
MH  - Amino Acid Sequence
MH  - Calcium/metabolism
MH  - Cell Line
MH  - Cells, Cultured
MH  - Chemokines, CC/*physiology
MH  - *Chemotaxis, Leukocyte
MH  - Humans
MH  - Kidney
MH  - Kinetics
MH  - Molecular Sequence Data
MH  - Open Reading Frames
MH  - Receptors, CCR
MH  - Receptors, Chemokine/chemistry/*genetics/*immunology
MH  - Recombinant Proteins/chemistry/metabolism
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - T-Lymphocytes/immunology/*physiology
EDAT- 1999/09/25 00:00
MHDA- 1999/09/25 00:01
CRDT- 1999/09/25 00:00
PHST- 1999/09/25 00:00 [pubmed]
PHST- 1999/09/25 00:01 [medline]
PHST- 1999/09/25 00:00 [entrez]
PST - ppublish
SO  - Blood. 1999 Oct 1;94(7):2533-6.