PMID- 10497278
OWN - NLM
STAT- MEDLINE
DCOM- 19991217
LR  - 20190501
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Linking)
VI  - 27
IP  - 20
DP  - 1999 Oct 15
TI  - Expression specificity of the mouse exonuclease 1 (mExo1) gene.
PG  - 4114-20
AB  - Genetic recombination involves either the homo-logous exchange of nearly
      identical chromosome regions or the direct alignment, annealing and ligation of
      processed DNA ends. These mechanisms are involved in repairing potentially lethal
      or mutagenic DNA damage and generating genetic diversity within the meiotic cell 
      population and antibody repertoire. We report here the identification of a mouse 
      gene, termed mExo1 for mouse exonuclease 1, which encodes a approximately 92 kDa 
      protein that shares homology to proteins of the RAD2 nuclease family, most
      notably human 5' to 3' exonuclease Hex1/hExo1, yeast exonuclease 1 (Exo1)
      proteins and Drosophila melanogaster Tosca. The mExo1 gene maps to distal
      chromosome 1, consistent with the recent mapping of the orthologous HEX1 / hEXO1 
      gene to chromosome 1q42-q43. mExo1 is expressed prominently in testis, an area of
      active homologous recombination, and spleen, a prominent lymphoid tissue. An
      increased level of mExo1 mRNA was observed during a stage of testis development
      where cells that are actively involved in meiotic recombination arise first and
      represent a significant proportion of the germ cell population. Comparative
      evaluation of the expression patterns of the human and mouse genes, combined with
      previous biochemical and yeast genetic studies, indicate that the Exo1-like
      proteins are important contributors to chromosome processing during mammalian DNA
      repair and recombination.
FAU - Lee, B I
AU  - Lee BI
AD  - Molecular and Structural Biology Division, Biology & Biotechnology Research
      Program, L-452, Lawrence Livermore National Laboratory, Livermore, CA 94551-9900,
      USA.
FAU - Shannon, M
AU  - Shannon M
FAU - Stubbs, L
AU  - Stubbs L
FAU - Wilson, D M 3rd
AU  - Wilson DM 3rd
LA  - eng
SI  - GENBANK/AJ238213
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - EC 3.1.- (EXO1 protein, human)
RN  - EC 3.1.- (Exodeoxyribonucleases)
RN  - EC 3.1.11.1 (exodeoxyribonuclease I)
RN  - EC 6.5.1.- (DNA Repair Enzymes)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosome Mapping
MH  - DNA Repair
MH  - DNA Repair Enzymes
MH  - Exodeoxyribonucleases/*genetics
MH  - *Gene Expression Regulation, Enzymologic
MH  - Hematopoiesis
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Recombination, Genetic
MH  - Sequence Alignment
PMC - PMC148681
EDAT- 1999/09/25 09:00
MHDA- 2001/03/28 10:01
CRDT- 1999/09/25 09:00
PHST- 1999/09/25 09:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1999/09/25 09:00 [entrez]
AID - gkc605 [pii]
AID - 10.1093/nar/27.20.4114 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 1999 Oct 15;27(20):4114-20. doi: 10.1093/nar/27.20.4114.