PMID- 10497217
OWN - NLM
STAT- MEDLINE
DCOM- 19991102
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 40
DP  - 1999 Oct 1
TI  - Identification of a human histone acetyltransferase related to monocytic leukemia
      zinc finger protein.
PG  - 28528-36
AB  - We describe here the identification and functional characterization of a novel
      human histone acetyltransferase, termed MORF (monocytic leukemia zinc finger
      protein-related factor). MORF is a 1781-residue protein displaying significant
      sequence similarity to MOZ (monocytic leukemia zinc finger protein). MORF is
      ubiquitously expressed in adult human tissues, and its gene is located at human
      chromosome band 10q22. MORF has intrinsic histone acetyltransferase activity. In 
      addition to its histone acetyltransferase domain, MORF possesses a strong
      transcriptional repression domain at its N terminus and a highly potent
      activation domain at its C terminus. Therefore, MORF is a novel histone
      acetyltransferase that contains multiple functional domains and may be involved
      in both positive and negative regulation of transcription.
FAU - Champagne, N
AU  - Champagne N
AD  - Molecular Oncology Group, Department of Medicine, McGill University Health
      Center, Montreal, Quebec H3A 1A1, Canada.
FAU - Bertos, N R
AU  - Bertos NR
FAU - Pelletier, N
AU  - Pelletier N
FAU - Wang, A H
AU  - Wang AH
FAU - Vezmar, M
AU  - Vezmar M
FAU - Yang, Y
AU  - Yang Y
FAU - Heng, H H
AU  - Heng HH
FAU - Yang, X J
AU  - Yang XJ
LA  - eng
SI  - GENBANK/AF113514
SI  - GENBANK/AF119230
SI  - GENBANK/AF119231
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA, Complementary)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - EC 2.3.1.- (Acetyltransferases)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
SB  - IM
MH  - 3T3 Cells
MH  - Acetyltransferases/chemistry/genetics/*metabolism
MH  - Adult
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Line
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 10
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Histone Acetyltransferases
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Saccharomyces cerevisiae Proteins
MH  - Sequence Homology, Amino Acid
MH  - Substrate Specificity
EDAT- 1999/09/25 00:00
MHDA- 1999/09/25 00:01
CRDT- 1999/09/25 00:00
PHST- 1999/09/25 00:00 [pubmed]
PHST- 1999/09/25 00:01 [medline]
PHST- 1999/09/25 00:00 [entrez]
AID - 10.1074/jbc.274.40.28528 [doi]
AID - S0021-9258(19)52080-4 [pii]
PST - ppublish
SO  - J Biol Chem. 1999 Oct 1;274(40):28528-36. doi: 10.1074/jbc.274.40.28528.