PMID- 10496080
OWN - NLM
STAT- MEDLINE
DCOM- 19991020
LR  - 20061115
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 44
IP  - 5
DP  - 1999
TI  - Isolation and localization of an IDDMK1,2-22-related human endogenous retroviral 
      gene, and identification of a CA repeat marker at its locus.
PG  - 343-7
AB  - We intended to confirm genetically the involvement of the IDDMK1,2-22 gene in the
      pathogenesis of insulin-dependent diabetes mellitus (IDDM). For this purpose, we 
      isolated a human endogenous retrovirus gene, possibly corresponding to
      IDDMK1,2-22. The isolated gene showed 99.8% and 99.7% homologies in nucleotide
      sequences to a part of the env region and of the 3'-LTR region, respectively,
      compared to those of IDDMK1,2-22 deposited in GenBank. The gene also showed a
      close relation to HERV-K18, of which the 3'-LTR sequence gave 99.5% homology. It 
      seemed likely that these genes represented the same single gene. The newly
      isolated gene was present in the first intron of the CD48 gene and was located on
      chromosome 1q21.2-q22. A CA repeat marker was found approximately 20 kb upstream 
      from the 5'-end of the 5'-LTR of the gene.
FAU - Hasuike, S
AU  - Hasuike S
AD  - Department of Obstetrics and Gynecology, Asahikawa Medical College, Japan.
FAU - Miura, K
AU  - Miura K
FAU - Miyoshi, O
AU  - Miyoshi O
FAU - Miyamoto, T
AU  - Miyamoto T
FAU - Niikawa, N
AU  - Niikawa N
FAU - Jinno, Y
AU  - Jinno Y
FAU - Ishikawa, M
AU  - Ishikawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (DNA, Viral)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 1
MH  - DNA, Viral/genetics
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - *Dinucleotide Repeats
MH  - Endogenous Retroviruses/*genetics
MH  - Genes, env
MH  - Genetic Markers
MH  - Humans
MH  - Repetitive Sequences, Nucleic Acid
MH  - Sequence Homology, Nucleic Acid
EDAT- 1999/09/25 00:00
MHDA- 1999/09/25 00:01
CRDT- 1999/09/25 00:00
PHST- 1999/09/25 00:00 [pubmed]
PHST- 1999/09/25 00:01 [medline]
PHST- 1999/09/25 00:00 [entrez]
AID - 10.1007/s100380050173 [doi]
PST - ppublish
SO  - J Hum Genet. 1999;44(5):343-7. doi: 10.1007/s100380050173.