PMID- 10496079
OWN - NLM
STAT- MEDLINE
DCOM- 19991020
LR  - 20191210
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 44
IP  - 5
DP  - 1999
TI  - Cloning and characterization of human and mouse PROSC (proline synthetase
      co-transcribed) genes.
PG  - 337-42
AB  - Large-scale DNA sequencing, coupled with in silico gene trapping, is a robust
      approach to identifying unknown genes in selected genomic regions. Using this
      approach we have isolated a novel human gene, PROSC (for proline synthetase
      co-transcribed [bacterial homolog]), from human chromosome 8p11.2, and its mouse 
      counterpart. The human PROSC gene spanned 17 kb of genomic DNA; its cDNA was 2530
      bp long, with 8 exons that included an open reading frame of 825 bp (275 amino
      acids). The mouse cDNA (Prosc), 1995 bp long, was predicted to encode 274 amino
      acids. PROSC is ubiquitously expressed in human tissues and has been highly
      conserved among divergent species from bacteria to mammals, suggesting its
      important cellular function. The gene product is likely to be a soluble
      cytoplasmic protein, but its function remains to be determined.
FAU - Ikegawa, S
AU  - Ikegawa S
AD  - Laboratory of Genome Medicine, University of Tokyo, Japan.
      sikegawa@ims.u-tokyo.ac.jp
FAU - Isomura, M
AU  - Isomura M
FAU - Koshizuka, Y
AU  - Koshizuka Y
FAU - Nakamura, Y
AU  - Nakamura Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (DNA, Complementary)
RN  - 0 (PLPBP protein, human)
RN  - 0 (Phosphate-Binding Proteins)
RN  - 0 (Plpbp protein, mouse)
RN  - 0 (Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Arabidopsis/genetics
MH  - Base Sequence
MH  - Caenorhabditis elegans/genetics
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 8
MH  - Cloning, Molecular
MH  - DNA, Complementary/chemistry/genetics
MH  - Escherichia coli/genetics
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phosphate-Binding Proteins
MH  - Proteins/chemistry/*genetics
MH  - Pseudomonas aeruginosa/genetics
MH  - Saccharomyces cerevisiae/genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Transcription, Genetic
EDAT- 1999/09/25 00:00
MHDA- 1999/09/25 00:01
CRDT- 1999/09/25 00:00
PHST- 1999/09/25 00:00 [pubmed]
PHST- 1999/09/25 00:01 [medline]
PHST- 1999/09/25 00:00 [entrez]
AID - 10.1007/s100380050172 [doi]
PST - ppublish
SO  - J Hum Genet. 1999;44(5):337-42. doi: 10.1007/s100380050172.