PMID- 10495270
OWN - NLM
STAT- MEDLINE
DCOM- 20000316
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 87
IP  - 1-2
DP  - 1999 Sep
TI  - Dickkopf genes are co-ordinately expressed in mesodermal lineages.
PG  - 45-56
AB  - Dickkopf-1 (dkk-1) is member of a novel family of secreted proteins and functions
      in head induction during Xenopus embryogenesis, acting as a potent inhibitor of
      Wnt signalling. Here we report: (1) the isolation of two additional murine
      members of the dkk family, dkk-2 and dkk-3; and (2) analysis of adult and
      embryonic gene expression of mouse dkk-1,-2, and -3, Xenopus dkk-1 as well as
      chicken dkk-3. Comparative developmental analyses of the dkk-1, dkk-2 and dkk-3
      in mice indicate that these genes are both temporally and spatially regulated.
      They define overlapping deep domains in mesenchymal lineages suggesting a
      co-ordinated mode of action. All dkks show distinct and elevated expression
      patterns in tissues that mediate epithelial- mesenchyme transformations
      suggesting that they may participate in heart, tooth, hair and whisker follicle, 
      limb and bone induction. In the limb buds expression of these genes are found in 
      regions of programmed cell death. In a given organ, dkk-1 tends to be the
      earliest member expressed. Comparison with Xenopus dkk-1 and chicken dkk-3 shows 
      evolutionarily conserved expression patterns. Our observations indicate that dkk 
      genes constitute a new family of secreted proteins that may mediate inductive
      interactions between epithelial and mesenchymal cells.
FAU - Monaghan, A P
AU  - Monaghan AP
AD  - Division of Molecular Biology of the Cell I, Deutsches Krebsforschungszentrum, Im
      Neuenheimer Feld 280, D-69120, Heidelberg, Germany.
FAU - Kioschis, P
AU  - Kioschis P
FAU - Wu, W
AU  - Wu W
FAU - Zuniga, A
AU  - Zuniga A
FAU - Bock, D
AU  - Bock D
FAU - Poustka, A
AU  - Poustka A
FAU - Delius, H
AU  - Delius H
FAU - Niehrs, C
AU  - Niehrs C
LA  - eng
SI  - GENBANK/AJ243963
SI  - GENBANK/AJ243964
PT  - Journal Article
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Dkk1 protein, mouse)
RN  - 0 (Dkk2 protein, mouse)
RN  - 0 (Dkk3 protein, mouse)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Ectoderm/metabolism
MH  - Epithelial Cells/metabolism
MH  - *Gene Expression Regulation, Developmental
MH  - In Situ Hybridization
MH  - Intercellular Signaling Peptides and Proteins
MH  - Mesoderm/*metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Proteins/*genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Homology, Amino Acid
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 1999/09/24 09:00
MHDA- 2000/03/18 09:00
CRDT- 1999/09/24 09:00
PHST- 1999/09/24 09:00 [pubmed]
PHST- 2000/03/18 09:00 [medline]
PHST- 1999/09/24 09:00 [entrez]
AID - S0925-4773(99)00138-0 [pii]
AID - 10.1016/s0925-4773(99)00138-0 [doi]
PST - ppublish
SO  - Mech Dev. 1999 Sep;87(1-2):45-56. doi: 10.1016/s0925-4773(99)00138-0.