PMID- 10493742
OWN - NLM
STAT- MEDLINE
DCOM- 19991014
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 19
DP  - 1999 Oct 1
TI  - Olfactory neurons expressing closely linked and homologous odorant receptor genes
      tend to project their axons to neighboring glomeruli on the olfactory bulb.
PG  - 8409-18
AB  - We have characterized two separate odorant receptor (OR) gene clusters to examine
      how olfactory neurons expressing closely linked and homologous OR genes project
      their axons to the olfactory bulb. Murine OR genes, MOR28, MOR10, and MOR83,
      share 75-95% similarities in the amino acid sequences and are tightly linked on
      chromosome 14. In situ hybridization has demonstrated that the three genes are
      expressed in the same zone, at the most dorsolateral and ventromedial portions of
      the olfactory epithelium, and are rarely expressed simultaneously in individual
      neurons. Furthermore, we have found that olfactory neurons expressing MOR28,
      MOR10, or MOR83 project their axons to very close but distinct subsets of
      glomeruli on the medial and lateral sides of the olfactory bulb. Similar results 
      have been obtained with another murine OR gene cluster for A16 and MOR18 on
      chromosome 2, sharing 91% similarity in the amino acid sequences. These results
      may indicate an intriguing possibility that olfactory neurons expressing
      homologous OR genes within a cluster tend to converge their axons to proximal but
      distinct subsets of glomeruli. These lines of study will shed light on the
      molecular basis of topographical projection of olfactory neurons to the olfactory
      bulb.
FAU - Tsuboi, A
AU  - Tsuboi A
AD  - Department of Biophysics and Biochemistry, Graduate School of Science, University
      of Tokyo, Tokyo 113-0032, Japan.
FAU - Yoshihara, S
AU  - Yoshihara S
FAU - Yamazaki, N
AU  - Yamazaki N
FAU - Kasai, H
AU  - Kasai H
FAU - Asai-Tsuboi, H
AU  - Asai-Tsuboi H
FAU - Komatsu, M
AU  - Komatsu M
FAU - Serizawa, S
AU  - Serizawa S
FAU - Ishii, T
AU  - Ishii T
FAU - Matsuda, Y
AU  - Matsuda Y
FAU - Nagawa, F
AU  - Nagawa F
FAU - Sakano, H
AU  - Sakano H
LA  - eng
SI  - GENBANK/AB030892
SI  - GENBANK/AB030893
SI  - GENBANK/AB030894
SI  - GENBANK/AB030895
SI  - GENBANK/AB030896
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for
      Neuroscience
JID - 8102140
RN  - 0 (DNA Primers)
RN  - 0 (Receptors, Odorant)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Axons/*physiology
MH  - Base Sequence
MH  - *Chromosome Mapping
MH  - DNA Primers
MH  - Exons
MH  - *Gene Expression Regulation
MH  - Gene Library
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Olfactory Bulb/*physiology
MH  - Olfactory Mucosa/cytology/physiology
MH  - Olfactory Receptor Neurons/cytology/*physiology
MH  - Receptors, Odorant/*genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
PMC - PMC6783044
EDAT- 1999/09/24 00:00
MHDA- 1999/09/24 00:01
CRDT- 1999/09/24 00:00
PHST- 1999/09/24 00:00 [pubmed]
PHST- 1999/09/24 00:01 [medline]
PHST- 1999/09/24 00:00 [entrez]
PST - ppublish
SO  - J Neurosci. 1999 Oct 1;19(19):8409-18.