PMID- 10491954
OWN - NLM
STAT- MEDLINE
DCOM- 19991105
LR  - 20190822
IS  - 0378-5955 (Print)
IS  - 0378-5955 (Linking)
VI  - 135
IP  - 1-2
DP  - 1999 Sep
TI  - Vestibular responses to linear acceleration are absent in otoconia-deficient
      C57BL/6JEi-het mice.
PG  - 56-60
AB  - UNLABELLED: Vestibular evoked potentials (VsEPs) were measured in normal mice and
      in mice homozygous for the head tilt mutation (het/het, abbr. het). The het mice 
      lack otoconia, the inertial mass critical for natural stimulation of inner ear
      gravity receptors. Our findings demonstrate that vestibular neural responses to
      pulsed linear acceleration are absent in het mice. THE RESULTS: (1) confirm that 
      adequate sensory stimuli fail to activate gravity receptors in the het model; and
      (2) serve as definitive evidence that far-field vestibular responses to pulsed
      linear acceleration depend critically on otolith end organs. The C57BL/6JEi-het
      mouse may be an excellent model of gravity receptor sensory deprivation.
FAU - Jones, S M
AU  - Jones SM
AD  - Department of Surgery/ENT, University of Missouri School of Medicine, Columbia
      65212, USA.
FAU - Erway, L C
AU  - Erway LC
FAU - Bergstrom, R A
AU  - Bergstrom RA
FAU - Schimenti, J C
AU  - Schimenti JC
FAU - Jones, T A
AU  - Jones TA
LA  - eng
GR  - HD24374/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
SB  - IM
SB  - S
MH  - *Acceleration
MH  - Animals
MH  - Evoked Potentials/physiology
MH  - Evoked Potentials, Auditory, Brain Stem/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Mutation
MH  - Otolithic Membrane/*physiology
MH  - Vestibule, Labyrinth/*physiology
OTO - NASA
OT  - NASA Discipline Neuroscience
OT  - Non-NASA Center
IR  - Jones TA
FIR - Jones, T A
IRAD- U MO, Columbia
EDAT- 1999/09/24 00:00
MHDA- 1999/09/24 00:01
CRDT- 1999/09/24 00:00
PHST- 1999/09/24 00:00 [pubmed]
PHST- 1999/09/24 00:01 [medline]
PHST- 1999/09/24 00:00 [entrez]
AID - S0378-5955(99)00090-8 [pii]
AID - 10.1016/s0378-5955(99)00090-8 [doi]
PST - ppublish
SO  - Hear Res. 1999 Sep;135(1-2):56-60. doi: 10.1016/s0378-5955(99)00090-8.