PMID- 10491328
OWN - NLM
STAT- MEDLINE
DCOM- 19991021
LR  - 20071114
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 263
IP  - 2
DP  - 1999 Sep 24
TI  - Cloning and characterization of a mammalian
      N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal
      tissue.
PG  - 543-9
AB  - Using the sequences of a galactose 6-O-sulfotransferase and an
      N-acetylglucosamine 6-O-sulfotransferase as probes in an EST approach, we have
      identified a highly related cDNA in human and an apparent orthologue in mouse.
      The cDNAs predict type II transmembrane proteins that constitute new members of
      the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family. Members of this family
      have previously been implicated in the sulfation of GAG chains within
      proteoglycans and the sulfation of O-linked chains within sialomucin ligands for 
      l-selectin. Expression of the newly identified cDNA in COS cells led to the
      addition of sulfate to C-6 of GlcNAc in an acceptor glycoprotein. The tissue
      expression of transcripts corresponding to the cDNA was highly restricted to the 
      small intestine and colon in humans. Based on these characteristics, the novel
      sulfotransferase is designated I-GlcNAc6ST for intestinal GlcNAc
      6-O-sulfotransferase.
CI  - Copyright 1999 Academic Press.
FAU - Lee, J K
AU  - Lee JK
AD  - Department of Anatomy and Program in Immunology, University of California, San
      Francisco, California, 94143, USA.
FAU - Bhakta, S
AU  - Bhakta S
FAU - Rosen, S D
AU  - Rosen SD
FAU - Hemmerich, S
AU  - Hemmerich S
LA  - eng
SI  - GENBANK/AF176838
SI  - GENBANK/AF176839
SI  - GENBANK/AF176840
SI  - GENBANK/AF176841
GR  - R01GM5741/GM/NIGMS NIH HHS/United States
GR  - R37GM23547/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA, Complementary)
RN  - 0 (Mucins)
RN  - 145895-89-2 (sulfated glycoprotein p50)
RN  - EC 2.8.2.- (Sulfotransferases)
RN  - EC 2.8.2.- (carbohydrate sulfotransferases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Conserved Sequence
MH  - DNA, Complementary/genetics
MH  - Expressed Sequence Tags
MH  - Humans
MH  - Intestines/*enzymology
MH  - Mice
MH  - Molecular Sequence Data
MH  - Mucins/metabolism
MH  - Protein Processing, Post-Translational
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
MH  - Substrate Specificity
MH  - Sulfotransferases/*genetics/isolation & purification
MH  - Tissue Distribution
EDAT- 1999/09/24 00:00
MHDA- 1999/09/24 00:01
CRDT- 1999/09/24 00:00
PHST- 1999/09/24 00:00 [pubmed]
PHST- 1999/09/24 00:01 [medline]
PHST- 1999/09/24 00:00 [entrez]
AID - 10.1006/bbrc.1999.1324 [doi]
AID - S0006-291X(99)91324-4 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Sep 24;263(2):543-9. doi:
      10.1006/bbrc.1999.1324.