PMID- 10490716
OWN - NLM
STAT- MEDLINE
DCOM- 19991117
LR  - 20220129
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 88
IP  - 5
DP  - 1999 Oct 15
TI  - No evidence for allelic association between schizophrenia and a functional
      variant of the human dopamine beta-hydroxylase gene (DBH).
PG  - 557-9
AB  - Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to
      norepinepherine, has been proposed as being involved in the aetiology of
      schizophrenia. Previous work identified a functional polymorphism at nucleotide
      910 of the DBH gene that results in a codon change in the mature protein
      Ala304Ser, with the mutant allele being associated with a lower enzymatic
      activity. In this study we performed an RFLP analysis in an association study
      consisting of 178 unrelated schizophrenic patients and 178 unrelated control
      subjects, matched for age, sex, and ethnicity. The frequency of the Ser304 DBH
      allele was 0.10 in the patient group and 0.08 in the control group, with no
      significant allelic or genotypic association observed. Therefore, we were unable 
      to obtain evidence that this polymorphism contributes directly to susceptibility 
      to schizophrenia.
FAU - Williams, H J
AU  - Williams HJ
AD  - Neuropsychiatric Genetics Department, University of Wales College of Medicine,
      Cardiff, United Kingdom. wpchjw1@cardiff.ac.uk
FAU - Bray, N
AU  - Bray N
FAU - Murphy, K C
AU  - Murphy KC
FAU - Cardno, A G
AU  - Cardno AG
FAU - Jones, L A
AU  - Jones LA
FAU - Owen, M J
AU  - Owen MJ
LA  - eng
GR  - G9309834/MRC_/Medical Research Council/United Kingdom
GR  - G9810900/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
RN  - EC 1.14.17.1 (Dopamine beta-Hydroxylase)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Case-Control Studies
MH  - Dopamine beta-Hydroxylase/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Restriction Fragment Length
MH  - Schizophrenia/*genetics
EDAT- 1999/09/22 00:00
MHDA- 1999/09/22 00:01
CRDT- 1999/09/22 00:00
PHST- 1999/09/22 00:00 [pubmed]
PHST- 1999/09/22 00:01 [medline]
PHST- 1999/09/22 00:00 [entrez]
AID - 10.1002/(SICI)1096-8628(19991015)88:5<557::AID-AJMG22>3.0.CO;2-F [pii]
AID - 10.1002/(sici)1096-8628(19991015)88:5<557::aid-ajmg22>3.0.co;2-f [doi]
PST - ppublish
SO  - Am J Med Genet. 1999 Oct 15;88(5):557-9. doi:
      10.1002/(sici)1096-8628(19991015)88:5<557::aid-ajmg22>3.0.co;2-f.