PMID- 10490659
OWN - NLM
STAT- MEDLINE
DCOM- 20000203
LR  - 20190508
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 19
IP  - 10
DP  - 1999 Oct
TI  - The JIP group of mitogen-activated protein kinase scaffold proteins.
PG  - 7245-54
AB  - Activation of the c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated
      protein (MAP) kinases is mediated by a protein kinase cascade. This signaling
      mechanism may be coordinated by the interaction of components of the protein
      kinase cascade with scaffold proteins. The JNK-interacting protein (JIP) group of
      scaffold proteins selectively mediates signaling by the mixed-lineage kinase
      (MLK)-->MAP kinase kinase 7 (MKK7)-->JNK pathway. The scaffold proteins JIP1 and 
      JIP2 interact to form oligomeric complexes that accumulate in peripheral
      cytoplasmic projections extended at the cell surface. The JIP proteins function
      by aggregating components of a MAP kinase module (including MLK, MKK7, and JNK)
      and facilitate signal transmission by the protein kinase cascade.
FAU - Yasuda, J
AU  - Yasuda J
AD  - Howard Hughes Medical Institute, Program in Molecular Medicine, Department of
      Biochemistry and Molecular Biology, University of Massachusetts Medical School,
      Worcester, Massachusetts 01605, USA.
FAU - Whitmarsh, A J
AU  - Whitmarsh AJ
FAU - Cavanagh, J
AU  - Cavanagh J
FAU - Sharma, M
AU  - Sharma M
FAU - Davis, R J
AU  - Davis RJ
LA  - eng
SI  - GENBANK/AF136382
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (MAPK8IP1 protein, human)
RN  - 0 (MAPK8IP2 protein, human)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 7)
RN  - EC 2.7.12.2 (MAP2K7 protein, human)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Carrier Proteins/genetics/isolation & purification/*metabolism
MH  - Cell Compartmentation
MH  - Cloning, Molecular
MH  - JNK Mitogen-Activated Protein Kinases
MH  - MAP Kinase Kinase 7
MH  - MAP Kinase Kinase Kinases/*metabolism
MH  - Mitogen-Activated Protein Kinase Kinases/*metabolism
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - Molecular Sequence Data
MH  - Protein Binding
MH  - Protein Structure, Quaternary
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
PMC - PMC84717
EDAT- 1999/09/22 00:00
MHDA- 1999/09/22 00:01
CRDT- 1999/09/22 00:00
PHST- 1999/09/22 00:00 [pubmed]
PHST- 1999/09/22 00:01 [medline]
PHST- 1999/09/22 00:00 [entrez]
AID - 10.1128/mcb.19.10.7245 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1999 Oct;19(10):7245-54. doi: 10.1128/mcb.19.10.7245.