PMID- 10490605
OWN - NLM
STAT- MEDLINE
DCOM- 20000203
LR  - 20191210
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 19
IP  - 10
DP  - 1999 Oct
TI  - TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun 
      N-terminal kinase/stress-activated protein kinase activation through the germinal
      center kinase pathway.
PG  - 6665-72
AB  - Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are mediators of 
      many members of the TNF receptor superfamily and can activate both the nuclear
      factor kappaB (NF-kappaB) and stress-activated protein kinase (SAPK; also known
      as c-Jun N-terminal kinase) signal transduction pathways. We previously described
      the involvement of a TRAF-interacting molecule, TRAF-associated NF-kappaB
      activator (TANK), in TRAF2-mediated NF-kappaB activation. Here we show that TANK 
      synergized with TRAF2, TRAF5, and TRAF6 but not with TRAF3 in SAPK activation.
      TRAF2 and TANK individually formed weak interactions with germinal center kinase 
      (GCK)-related kinase (GCKR). However, when coexpressed, they formed a strong
      complex with GCKR, thereby providing a potential mechanism for TRAF and TANK
      synergy in GCKR-mediated SAPK activation, which is important in TNF family
      receptor signaling. Our results also suggest that TANK can form potential
      intermolecular as well as intramolecular interactions between its amino terminus 
      and carboxyl terminus. This study suggests that TANK is a regulatory molecule
      controlling the threshold of NF-kappaB and SAPK activities in response to
      activation of TNF receptors. In addition, CD40 activated endogenous GCKR in
      primary B cells, implicating GCK family proteins in CD40-mediated B-cell
      functions.
FAU - Chin, A I
AU  - Chin AI
AD  - Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of
      California Los Angeles, 90095, USA.
FAU - Shu, J
AU  - Shu J
FAU - Shan Shi, C
AU  - Shan Shi C
FAU - Yao, Z
AU  - Yao Z
FAU - Kehrl, J H
AU  - Kehrl JH
FAU - Cheng, G
AU  - Cheng G
LA  - eng
GR  - R01 GM057559/GM/NIGMS NIH HHS/United States
GR  - T32 GM008042/GM/NIGMS NIH HHS/United States
GR  - GM 08042/GM/NIGMS NIH HHS/United States
GR  - GM57559/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (CD40 Antigens)
RN  - 0 (Germinal Center Kinases)
RN  - 0 (Peptide Fragments)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (TANK protein, human)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 0 (TNF Receptor-Associated Factor 5)
RN  - 0 (TNF Receptor-Associated Factor 6)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinase 1)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
RN  - EC 2.7.11.25 (MAP3K1 protein, human)
RN  - EC 2.7.11.25 (Map3k1 protein, mouse)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 4)
RN  - EC 2.7.12.2 (MAP2K4 protein, human)
RN  - EC 2.7.12.2 (Map2k4 protein, mouse)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - B-Lymphocytes/metabolism
MH  - CD40 Antigens/metabolism
MH  - Enzyme Activation
MH  - Germinal Center/cytology
MH  - Germinal Center Kinases
MH  - Humans
MH  - Lymphocytes/*metabolism
MH  - *MAP Kinase Kinase 4
MH  - *MAP Kinase Kinase Kinase 1
MH  - MAP Kinase Kinase Kinases/metabolism
MH  - *MAP Kinase Signaling System
MH  - Mitogen-Activated Protein Kinase Kinases/metabolism
MH  - Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism
MH  - Palatine Tonsil/cytology
MH  - Peptide Fragments/metabolism
MH  - Protein-Serine-Threonine Kinases/*metabolism
MH  - Proteins/genetics/*metabolism
MH  - Receptors, Tumor Necrosis Factor/*metabolism
MH  - T-Lymphocytes/metabolism
MH  - TNF Receptor-Associated Factor 2
MH  - TNF Receptor-Associated Factor 5
MH  - TNF Receptor-Associated Factor 6
PMC - PMC84649
EDAT- 1999/09/22 00:00
MHDA- 1999/09/22 00:01
CRDT- 1999/09/22 00:00
PHST- 1999/09/22 00:00 [pubmed]
PHST- 1999/09/22 00:01 [medline]
PHST- 1999/09/22 00:00 [entrez]
AID - 10.1128/mcb.19.10.6665 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1999 Oct;19(10):6665-72. doi: 10.1128/mcb.19.10.6665.