PMID- 10490103
OWN - NLM
STAT- MEDLINE
DCOM- 19991001
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 98
IP  - 5
DP  - 1999 Sep 3
TI  - Structural basis for FGF receptor dimerization and activation.
PG  - 641-50
AB  - The crystal structure of FGF2 bound to a naturally occurring variant of FGF
      receptor 1 (FGFR1) consisting of immunoglobulin-like domains 2 (D2) and 3 (D3)
      has been determined at 2.8 A resolution. Two FGF2:FGFR1 complexes form a 2-fold
      symmetric dimer. Within each complex, FGF2 interacts extensively with D2 and D3
      as well as with the linker between the two domains. The dimer is stabilized by
      interactions between FGF2 and D2 of the adjoining complex and by a direct
      interaction between D2 of each receptor. A positively charged canyon formed by a 
      cluster of exposed basic residues likely represents the heparin-binding site. A
      general model for FGF- and heparin-induced FGFR dimerization is inferred from the
      crystal structure, unifying a wealth of biochemical data.
FAU - Plotnikov, A N
AU  - Plotnikov AN
AD  - Department of Pharmacology, New York University School of Medicine, New York
      10016, USA.
FAU - Schlessinger, J
AU  - Schlessinger J
FAU - Hubbard, S R
AU  - Hubbard SR
FAU - Mohammadi, M
AU  - Mohammadi M
LA  - eng
SI  - PDB/1CVS
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Ligands)
RN  - 0 (Muscle Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Peptides)
RN  - 0 (Receptors, Fibroblast Growth Factor)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 3AZ1VUF0Q7 (telokin)
RN  - 9005-49-6 (Heparin)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1)
RN  - EC 2.7.11.18 (Myosin-Light-Chain Kinase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Crystallography, X-Ray
MH  - Dimerization
MH  - Fibroblast Growth Factor 2/chemistry
MH  - Heparin/chemistry
MH  - Ligands
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - Muscle Proteins/chemistry
MH  - Myosin-Light-Chain Kinase
MH  - Peptide Fragments
MH  - Peptides
MH  - Protein Structure, Tertiary
MH  - Receptor Protein-Tyrosine Kinases/*chemistry/*physiology
MH  - Receptor, Fibroblast Growth Factor, Type 1
MH  - Receptors, Fibroblast Growth Factor/*chemistry/*physiology
MH  - Sequence Homology, Amino Acid
EDAT- 1999/09/18 00:00
MHDA- 1999/09/18 00:01
CRDT- 1999/09/18 00:00
PHST- 1999/09/18 00:00 [pubmed]
PHST- 1999/09/18 00:01 [medline]
PHST- 1999/09/18 00:00 [entrez]
AID - S0092-8674(00)80051-3 [pii]
AID - 10.1016/s0092-8674(00)80051-3 [doi]
PST - ppublish
SO  - Cell. 1999 Sep 3;98(5):641-50. doi: 10.1016/s0092-8674(00)80051-3.