PMID- 10490101
OWN - NLM
STAT- MEDLINE
DCOM- 19991001
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 98
IP  - 5
DP  - 1999 Sep 3
TI  - SOCS3 is essential in the regulation of fetal liver erythropoiesis.
PG  - 617-27
AB  - SOCS3 (CIS3/JAB2) is an SH2-containing protein that binds to the activation loop 
      of Janus kinases, inhibiting kinase activity, and thereby suppressing cytokine
      signaling. During embryonic development, SOCS3 is highly expressed in erythroid
      lineage cells and is Epo independent. Transgene-mediated expression blocks fetal 
      erythropoiesis, resulting in embryonic lethality. SOCS3 deletion results in an
      embryonic lethality at 12-16 days associated with marked erythrocytosis.
      Moreover, the in vitro proliferative capacity of progenitors is greatly
      increased. SOCS3-deficient fetal liver stem cells can reconstitute hematopoiesis 
      in lethally irradiated adults, indicating that its absence does not disturb bone 
      marrow erythropoiesis. Reconstitution of lymphoid lineages in JAK3-deficient mice
      also occurs normally. The results demonstrate that SOCS3 is critical in
      negatively regulating fetal liver hematopoiesis.
FAU - Marine, J C
AU  - Marine JC
AD  - Howard Hughes Medical Institute, and Department of Biochemistry, St. Jude
      Children's Research Hospital, Memphis, Tennessee 38105, USA.
FAU - McKay, C
AU  - McKay C
FAU - Wang, D
AU  - Wang D
FAU - Topham, D J
AU  - Topham DJ
FAU - Parganas, E
AU  - Parganas E
FAU - Nakajima, H
AU  - Nakajima H
FAU - Pendeville, H
AU  - Pendeville H
FAU - Yasukawa, H
AU  - Yasukawa H
FAU - Sasaki, A
AU  - Sasaki A
FAU - Yoshimura, A
AU  - Yoshimura A
FAU - Ihle, J N
AU  - Ihle JN
LA  - eng
GR  - CA21765/CA/NCI NIH HHS/United States
GR  - P01 HL53749/HL/NHLBI NIH HHS/United States
GR  - R01 DK42932/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Interleukin-2)
RN  - 0 (Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Socs3 protein, mouse)
RN  - 0 (Suppressor of Cytokine Signaling 3 Protein)
RN  - 0 (Suppressor of Cytokine Signaling Proteins)
RN  - 0 (Transcription Factors)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Erythropoiesis/*physiology
MH  - Flow Cytometry
MH  - *Gene Expression Regulation, Developmental
MH  - Hematopoiesis/physiology
MH  - In Situ Hybridization
MH  - Interleukin-2/pharmacology
MH  - Interleukin-4/pharmacology
MH  - Liver/*embryology/physiology
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Models, Genetic
MH  - Mutagenesis
MH  - Phenotype
MH  - Proteins/*genetics/*physiology
MH  - *Repressor Proteins
MH  - Suppressor of Cytokine Signaling 3 Protein
MH  - Suppressor of Cytokine Signaling Proteins
MH  - Time Factors
MH  - *Transcription Factors
MH  - Transfection
EDAT- 1999/09/18 00:00
MHDA- 1999/09/18 00:01
CRDT- 1999/09/18 00:00
PHST- 1999/09/18 00:00 [pubmed]
PHST- 1999/09/18 00:01 [medline]
PHST- 1999/09/18 00:00 [entrez]
AID - S0092-8674(00)80049-5 [pii]
AID - 10.1016/s0092-8674(00)80049-5 [doi]
PST - ppublish
SO  - Cell. 1999 Sep 3;98(5):617-27. doi: 10.1016/s0092-8674(00)80049-5.