PMID- 10490098
OWN - NLM
STAT- MEDLINE
DCOM- 19991001
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 98
IP  - 5
DP  - 1999 Sep 3
TI  - Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity
      under the control of Frizzled.
PG  - 585-95
AB  - We identified a seven-pass transmembrane receptor of the cadherin superfamily,
      designated Flamingo (Fmi), localized at cell-cell boundaries in the Drosophila
      wing. In the absence of Fmi, planar polarity was distorted. Before morphological 
      polarization of wing cells along the proximal-distal (P-D) axis, Fmi was
      redistributed predominantly to proximal and distal cell edges. This biased
      localization of Fmi appears to be driven by an imbalance of the activity of
      Frizzled (Fz) across the proximal/distal cell boundary. These results, together
      with phenotypes caused by ectopic expression of fz and fmi, suggest that cells
      acquire the P-D polarity by way of the Fz-dependent boundary localization of Fmi.
FAU - Usui, T
AU  - Usui T
AD  - Department of Biophysics, Faculty of Science, Japan.
FAU - Shima, Y
AU  - Shima Y
FAU - Shimada, Y
AU  - Shimada Y
FAU - Hirano, S
AU  - Hirano S
FAU - Burgess, R W
AU  - Burgess RW
FAU - Schwarz, T L
AU  - Schwarz TL
FAU - Takeichi, M
AU  - Takeichi M
FAU - Uemura, T
AU  - Uemura T
LA  - eng
SI  - GENBANK/AB028498
SI  - GENBANK/AB028499
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Cadherins)
RN  - 0 (Celsr2 protein, mouse)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Frizzled Receptors)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (fz protein, Drosophila)
RN  - 0 (stan protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cadherins/*physiology
MH  - Cell Adhesion
MH  - *Cell Polarity
MH  - Cells, Cultured
MH  - Conserved Sequence
MH  - Cytoskeleton/metabolism
MH  - Drosophila
MH  - *Drosophila Proteins
MH  - Frizzled Receptors
MH  - Gene Expression Regulation, Developmental
MH  - Membrane Proteins/*physiology
MH  - Mice
MH  - Models, Biological
MH  - Molecular Sequence Data
MH  - Mutagenesis
MH  - Receptors, G-Protein-Coupled
MH  - Sequence Homology, Amino Acid
MH  - Time Factors
MH  - Transfection
MH  - Wings, Animal/metabolism
EDAT- 1999/09/18 00:00
MHDA- 1999/09/18 00:01
CRDT- 1999/09/18 00:00
PHST- 1999/09/18 00:00 [pubmed]
PHST- 1999/09/18 00:01 [medline]
PHST- 1999/09/18 00:00 [entrez]
AID - S0092-8674(00)80046-X [pii]
AID - 10.1016/s0092-8674(00)80046-x [doi]
PST - ppublish
SO  - Cell. 1999 Sep 3;98(5):585-95. doi: 10.1016/s0092-8674(00)80046-x.