PMID- 10488738
OWN - NLM
STAT- MEDLINE
DCOM- 20000131
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 54
IP  - 2
DP  - 1999 Aug
TI  - Polymorphism of human CD1 genes.
PG  - 122-7
AB  - Human CD1 genes have been reported to be invariant or to show limited
      polymorphism. Recently, certain functions of CD1 antigens have been described to 
      include the presentation lipid and glycolipid antigens. These observations
      prompted a thorough survey of the genetic polymorphism in the five human CD1
      genes (CD1a-CD1e). Using polymerase chain reaction-single stranded conformational
      polymorphism (PCR-SSCP) combined with sequence analyses, exons 2 and 3 from
      CD1a-CD1e were characterized from a total of 110 unrelated healthy donors.
      Results showed that all five genes (CD1a-CD1e) are polymorphic in exon 2.
      Substitutions in CD1b and CD1c are silent, whereas, substitutions in CD1a, CD1d
      and CD1e result in amino acid replacements in the deduced protein products. CD1a 
      and CD1e polymorphisms are prevalent in the population. The substitutions in CD1a
      have characteristics that may influence interactions with beta2-microglobulin
      beta2-m) or accessory molecules. The substitution in CD1e is located in the
      region predicted to interact with ligands and may differentially impact the
      ability of CD1e alleles to bind antigen.
FAU - Han, M
AU  - Han M
AD  - Laboratory of Immunogenetics, National Institute of Allergy and Infectious
      Diseases, Twinbrook II Facility, National Institutes of Health, Rockville, MD
      20852, USA.
FAU - Hannick, L I
AU  - Hannick LI
FAU - DiBrino, M
AU  - DiBrino M
FAU - Robinson, M A
AU  - Robinson MA
LA  - eng
SI  - GENBANK/AF142665
SI  - GENBANK/AF142666
SI  - GENBANK/AF142667
SI  - GENBANK/AF142668
SI  - GENBANK/AF142669
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antigens, CD1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antigens, CD1/*genetics
MH  - Base Sequence
MH  - Humans
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - Polymorphism, Genetic/*immunology
EDAT- 1999/09/17 00:00
MHDA- 1999/09/17 00:01
CRDT- 1999/09/17 00:00
PHST- 1999/09/17 00:00 [pubmed]
PHST- 1999/09/17 00:01 [medline]
PHST- 1999/09/17 00:00 [entrez]
AID - 10.1034/j.1399-0039.1999.540202.x [doi]
PST - ppublish
SO  - Tissue Antigens. 1999 Aug;54(2):122-7. doi: 10.1034/j.1399-0039.1999.540202.x.