PMID- 10488343
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 4
IP  - 2
DP  - 1999 Aug
TI  - MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase
      to transduce anterior/posterior polarity signals in C. elegans.
PG  - 275-80
AB  - In C. elegans, a Wnt/WG-like signaling pathway down-regulates the TCF/LEF-related
      protein, POP-1, to specify posterior cell fates. Effectors of this signaling
      pathway include a beta-catenin homolog, WRM-1, and a conserved protein kinase,
      LIT-1. WRM-1 and LIT-1 form a kinase complex that can directly phosphorylate
      POP-1, but how signaling activates WRM-1/LIT-1 kinase is not yet known. Here we
      show that mom-4, a genetically defined effector of polarity signaling, encodes a 
      MAP kinase kinase kinase-related protein that stimulates the
      WRM-1/LIT-1-dependent phosphorylation of POP-1. LIT-1 kinase activity requires a 
      conserved residue analogous to an activating phosphorylation site in other
      kinases, including MAP kinases. These findings suggest that anterior/posterior
      polarity signaling in C. elegans may involve a MAP kinase-like signaling
      mechanism.
FAU - Shin, T H
AU  - Shin TH
AD  - University of Massachusetts Medical School, Program in Molecular Medicine,
      Worcester 01605, USA.
FAU - Yasuda, J
AU  - Yasuda J
FAU - Rocheleau, C E
AU  - Rocheleau CE
FAU - Lin, R
AU  - Lin R
FAU - Soto, M
AU  - Soto M
FAU - Bei, Y
AU  - Bei Y
FAU - Davis, R J
AU  - Davis RJ
FAU - Mello, C C
AU  - Mello CC
LA  - eng
SI  - GENBANK/AF143242
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Helminth Proteins)
RN  - 0 (High Mobility Group Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (WRM-1 protein, C elegans)
RN  - 0 (mom-4 protein, C elegans)
RN  - 0 (pop-1 protein, C elegans)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (lit-1 protein, C elegans)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Body Patterning
MH  - Caenorhabditis elegans/*embryology/*genetics
MH  - *Caenorhabditis elegans Proteins
MH  - Conserved Sequence
MH  - Cytoskeletal Proteins/*metabolism
MH  - DNA-Binding Proteins/chemistry/*metabolism
MH  - Embryo, Nonmammalian/*physiology
MH  - Endoderm/physiology
MH  - Enzyme Activation
MH  - Helminth Proteins/metabolism
MH  - High Mobility Group Proteins/chemistry/*metabolism
MH  - Membrane Proteins/chemistry/*genetics/*metabolism
MH  - Molecular Sequence Data
MH  - Phosphorylation
MH  - Protein-Serine-Threonine Kinases/*metabolism
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Transcription Factors/metabolism
EDAT- 1999/09/17 00:00
MHDA- 1999/09/17 00:01
CRDT- 1999/09/17 00:00
PHST- 1999/09/17 00:00 [pubmed]
PHST- 1999/09/17 00:01 [medline]
PHST- 1999/09/17 00:00 [entrez]
AID - S1097-2765(00)80375-5 [pii]
AID - 10.1016/s1097-2765(00)80375-5 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Aug;4(2):275-80. doi: 10.1016/s1097-2765(00)80375-5.