PMID- 10485894
OWN - NLM
STAT- MEDLINE
DCOM- 19991014
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 19
DP  - 1999 Sep 14
TI  - A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis.
PG  - 10729-34
AB  - We have identified a transcription factor specifically expressed in the
      developing vertebrate eye. We named this gene vax2 because of the high degree of 
      sequence similarity to the recently described vax1. Both in the human and mouse
      genomes, vax2 is localized in the vicinity of the emx1 gene. This mapping
      assignment, together with the previously reported colocalization of Vax1 and Emx2
      in mouse, indicates that the vax and the emx genes may be organized in clusters. 
      vax2 has a remarkable expression domain confined to the ventral portion of the
      prospective neural retina in mouse, human, and Xenopus. The overexpression of
      either the frog Xvax2 or the human VAX2 in Xenopus embryos leads to an aberrant
      eye phenotype and, in particular, determines a ventralizing effect on the
      developing eye. The expression domain of the transcription factor Xpax2, normally
      confined to the ventral developing retina, extends to the dorsal region of the
      retina after overexpression of vax2. On the other hand, the expression of Xvent2,
      a molecular marker of the dorsal retina, is strongly reduced. Furthermore, vax2
      overexpression induces a striking expansion of the optic stalk, a structure
      deriving from the ventralmost region of the eye vesicle. Altogether, these data
      indicate that vax2 plays a crucial role in eye development and, in particular, in
      the specification of the ventral optic vesicle.
FAU - Barbieri, A M
AU  - Barbieri AM
AD  - Telethon Institute of Genetics and Medicine, San Raffaele Biomedical Science
      Park, 20132 Milan, Italy.
FAU - Lupo, G
AU  - Lupo G
FAU - Bulfone, A
AU  - Bulfone A
FAU - Andreazzoli, M
AU  - Andreazzoli M
FAU - Mariani, M
AU  - Mariani M
FAU - Fougerousse, F
AU  - Fougerousse F
FAU - Consalez, G G
AU  - Consalez GG
FAU - Borsani, G
AU  - Borsani G
FAU - Beckmann, J S
AU  - Beckmann JS
FAU - Barsacchi, G
AU  - Barsacchi G
FAU - Ballabio, A
AU  - Ballabio A
FAU - Banfi, S
AU  - Banfi S
LA  - eng
SI  - GENBANK/AJ238649
SI  - GENBANK/Y17791
SI  - GENBANK/Y17792
GR  - TGM06S01/Telethon/Italy
GR  - TGM97000/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA, Complementary)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (VAX2 protein, human)
RN  - 0 (Vax2 protein, mouse)
RN  - 0 (Xenopus Proteins)
RN  - 0 (vax2 protein, Xenopus)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Body Patterning/genetics
MH  - DNA, Complementary/analysis
MH  - Eye/*embryology/metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Genetic Linkage
MH  - Homeodomain Proteins/*genetics/*metabolism/*physiology
MH  - Humans
MH  - In Situ Hybridization
MH  - Larva
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phenotype
MH  - Physical Chromosome Mapping
MH  - Retina/embryology/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Time Factors
MH  - Tissue Distribution
MH  - Xenopus
MH  - *Xenopus Proteins
PMC - PMC17951
EDAT- 1999/09/15 00:00
MHDA- 1999/09/15 00:01
CRDT- 1999/09/15 00:00
PHST- 1999/09/15 00:00 [pubmed]
PHST- 1999/09/15 00:01 [medline]
PHST- 1999/09/15 00:00 [entrez]
AID - 10.1073/pnas.96.19.10729 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10729-34. doi:
      10.1073/pnas.96.19.10729.