PMID- 10485890
OWN - NLM
STAT- MEDLINE
DCOM- 19991014
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 19
DP  - 1999 Sep 14
TI  - Identification of a zinc finger protein whose subcellular distribution is
      regulated by serum and nerve growth factor.
PG  - 10705-10
AB  - A subclass of zinc finger proteins containing a unique protein motif called the
      positive regulatory (PR) domain has been described. The members include the
      PRDI-BF1/Blimp-1 protein, the Caenorhabditis elegans egl-43 and EVI1 gene
      products, and the retinoblastoma interacting protein RIZ. Here we describe a
      member of this family, SC-1, that exhibits several distinctive features. First,
      SC-1 interacts with the p75 neurotrophin receptor and is redistributed from the
      cytoplasm to the nucleus after nerve growth factor (NGF) treatment of transfected
      COS cells. The translocation of SC-1 to the nucleus was specific for p75, as NGF 
      binding to the TrkA receptor did not lead to nuclear localization of SC-1. Thus, 
      SC-1 provides a downstream transducer for the effects of NGF through the p75
      neurotrophin receptor. Under normal growth conditions, SC-1 was found
      predominantly in the cytoplasm. On serum-starvation, SC-1 also translocated into 
      the nucleus. A direct correlation between nuclear expression of SC-1 with the
      loss of BrdUrd incorporation was observed. These results imply that SC-1 may be
      involved in events associated with growth arrest.
FAU - Chittka, A
AU  - Chittka A
AD  - Cell Biology Program, Weill Graduate School of Cornell University Medical
      College, New York, NY 10021, USA.
FAU - Chao, M V
AU  - Chao MV
LA  - eng
SI  - GENBANK/AF176023
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carrier Proteins)
RN  - 0 (Culture Media, Serum-Free)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Prdm4 protein, rat)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Bromodeoxyuridine/metabolism
MH  - COS Cells
MH  - Carrier Proteins/*chemistry/*metabolism
MH  - Cell Line
MH  - Cell Nucleus/metabolism
MH  - Culture Media, Serum-Free/metabolism
MH  - Cytoplasm/metabolism
MH  - DNA, Complementary/metabolism
MH  - DNA-Binding Proteins
MH  - Humans
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/*metabolism
MH  - Neurotrophin 3
MH  - Nuclear Proteins
MH  - Proto-Oncogene Proteins/metabolism
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - Receptor, Nerve Growth Factor
MH  - Receptor, trkA
MH  - Receptors, Nerve Growth Factor/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Time Factors
MH  - Transcription Factors
MH  - *Zinc Fingers
PMC - PMC17947
EDAT- 1999/09/15 00:00
MHDA- 1999/09/15 00:01
CRDT- 1999/09/15 00:00
PHST- 1999/09/15 00:00 [pubmed]
PHST- 1999/09/15 00:01 [medline]
PHST- 1999/09/15 00:00 [entrez]
AID - 10.1073/pnas.96.19.10705 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10705-10. doi:
      10.1073/pnas.96.19.10705.