PMID- 10485844
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 13
IP  - 17
DP  - 1999 Sep 1
TI  - Twist is a potential oncogene that inhibits apoptosis.
PG  - 2207-17
AB  - Oncogene activation increases susceptibility to apoptosis. Thus, tumorigenesis
      must depend, in part, on compensating mutations that protect from programmed cell
      death. A functional screen for cDNAs that could counteract the proapoptotic
      effects of the myc oncogene identified two related bHLH family members, Twist and
      Dermo1. Both of these proteins inhibited oncogene- and p53-dependent cell death. 
      Twist expression bypassed p53-induced growth arrest. These effects correlated
      with an ability of Twist to interfere with activation of a p53-dependent reporter
      and to impair induction of p53 target genes in response to DNA damage. An
      underlying explanation for this observation may be provided by the ability of
      Twist to reduce expression of the ARF tumor suppressor. Thus, Twist may affect
      p53 indirectly through modulation of the ARF/MDM2/p53 pathway. Consistent with a 
      role as a potential oncoprotein, Twist expression promoted colony formation of
      E1A/ras-transformed mouse embryo fibroblasts (MEFs) in soft agar. Furthermore,
      Twist was inappropriately expressed in 50% of rhabdomyosarcomas, a tumor that
      arises from skeletal muscle precursors that fail to differentiate. Twist is known
      to block myogenic differentiation. Thus, Twist may play multiple roles in the
      formation of rhabdomyosarcomas, halting terminal differentiation, inhibiting
      apoptosis, and interfering with the p53 tumor-suppressor pathway.
FAU - Maestro, R
AU  - Maestro R
AD  - Experimental Oncology 1, Centro di Riferimento Oncologico, 33081 Aviano, Italy.
FAU - Dei Tos, A P
AU  - Dei Tos AP
FAU - Hamamori, Y
AU  - Hamamori Y
FAU - Krasnokutsky, S
AU  - Krasnokutsky S
FAU - Sartorelli, V
AU  - Sartorelli V
FAU - Kedes, L
AU  - Kedes L
FAU - Doglioni, C
AU  - Doglioni C
FAU - Beach, D H
AU  - Beach DH
FAU - Hannon, G J
AU  - Hannon GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Nuclear Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (TWIST1 protein, human)
RN  - 0 (TWIST2 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 0 (Twist-Related Protein 1)
RN  - 0 (Twist2 protein, mouse)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Cell Division
MH  - Cell Line
MH  - Cell Transformation, Neoplastic
MH  - Fibroblasts
MH  - Gene Deletion
MH  - Genes, myc
MH  - Genes, p53
MH  - Genes, ras
MH  - Helix-Loop-Helix Motifs
MH  - Humans
MH  - Mice
MH  - *Nuclear Proteins
MH  - *Oncogenes
MH  - Rats
MH  - *Repressor Proteins
MH  - Rhabdomyosarcoma/genetics
MH  - Transcription Factors/genetics/*metabolism
MH  - Tumor Suppressor Protein p53/metabolism
MH  - Twist-Related Protein 1
PMC - PMC317004
EDAT- 1999/09/15 00:00
MHDA- 1999/09/15 00:01
CRDT- 1999/09/15 00:00
PHST- 1999/09/15 00:00 [pubmed]
PHST- 1999/09/15 00:01 [medline]
PHST- 1999/09/15 00:00 [entrez]
AID - 10.1101/gad.13.17.2207 [doi]
PST - ppublish
SO  - Genes Dev. 1999 Sep 1;13(17):2207-17. doi: 10.1101/gad.13.17.2207.