PMID- 10485649
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20220410
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 11
IP  - 2
DP  - 1999 Aug
TI  - Development of lupus-like autoimmune diseases by disruption of the PD-1 gene
      encoding an ITIM motif-carrying immunoreceptor.
PG  - 141-51
AB  - PD-1, a 55 kDa transmembrane protein containing an immunoreceptor tyrosine-based 
      inhibitory motif, is induced in lymphocytes and monocytic cells following
      activation. Aged C57BL/6(B6)-PD-1(-/-) congenic mice spontaneously developed
      characteristic lupus-like proliferative arthritis and glomerulonephritis with
      predominant IgG3 deposition, which were markedly accelerated by introduction of a
      Fas mutation (lpr). Introduction of a PD-1 null mutation into the 2C-TCR
      (anti-H-2Ld) transgenic mice of the H-2(b/d) background resulted in the chronic
      and systemic graft-versus-host-like disease. Furthermore, CD8+ 2C-TCR+ PD-1(-/-) 
      T cells exhibited markedly augmented proliferation in vitro in response to H-2d
      allogenic cells. Collectively, it is suggested that PD-1 is involved in the
      maintenance of peripheral self-tolerance by serving as a negative regulator of
      immune responses.
FAU - Nishimura, H
AU  - Nishimura H
AD  - Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.
FAU - Nose, M
AU  - Nose M
FAU - Hiai, H
AU  - Hiai H
FAU - Minato, N
AU  - Minato N
FAU - Honjo, T
AU  - Honjo T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Antigens, Surface)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (H-2 Antigens)
RN  - 0 (Pdcd1 protein, mouse)
RN  - 0 (Programmed Cell Death 1 Receptor)
RN  - 0 (Proteins)
SB  - IM
MH  - Animals
MH  - *Antigens, Surface
MH  - Apoptosis Regulatory Proteins
MH  - Arthritis, Rheumatoid/*etiology
MH  - Genetic Linkage
MH  - H-2 Antigens/genetics
MH  - Immune Tolerance
MH  - Lupus Nephritis/*etiology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred MRL lpr
MH  - Mice, Transgenic
MH  - Programmed Cell Death 1 Receptor
MH  - Proteins/genetics/*physiology
MH  - T-Lymphocytes/immunology
EDAT- 1999/09/15 00:00
MHDA- 1999/09/15 00:01
CRDT- 1999/09/15 00:00
PHST- 1999/09/15 00:00 [pubmed]
PHST- 1999/09/15 00:01 [medline]
PHST- 1999/09/15 00:00 [entrez]
AID - S1074-7613(00)80089-8 [pii]
AID - 10.1016/s1074-7613(00)80089-8 [doi]
PST - ppublish
SO  - Immunity. 1999 Aug;11(2):141-51. doi: 10.1016/s1074-7613(00)80089-8.