PMID- 10485469
OWN - NLM
STAT- MEDLINE
DCOM- 19990930
LR  - 20190816
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 17
DP  - 1999 Sep 1
TI  - AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid
      leukemia with t(11;17)(q23;q25).
PG  - 4261-5
AB  - The t(11;17) has been described in patients with acute myeloid leukemia (AML),
      and the AF17 gene was previously cloned as a fusion partner of the MLL gene in
      t(11;17)(q23;q21)-AML. We analyzed one patient with de novo AML and one with
      therapy-related AML with t(11;17)(q23;q25) and identified the AF17q25 gene on
      chromosome 17q25, a putative septin family gene, fused with MLL. AF17q25 encoded 
      at least three kinds of proteins [type I (568 a.a.), type II (594 a.a.), and type
      III (574 a.a.)] that contained two kinds of different amino acid sequences at the
      COOH terminus. The MLL-AF17q25 fusion transcript consisted of type I AF17q25
      transcript. The AF17q25 protein is homologous to septin family proteins,
      including H5, NEDD5, CDC10, and hCDCrel, which is one of the fusion partners of
      MLL in t(11;22)(q23;q11)-AML. These results suggest that AF17q25 and hCDCrel
      might define a new septin family particularly involved in the pathogenesis of
      11q23-associated leukemia.
FAU - Taki, T
AU  - Taki T
AD  - Department of Pediatrics, Faculty of Medicine, University of Tokyo, Japan.
FAU - Ohnishi, H
AU  - Ohnishi H
FAU - Shinohara, K
AU  - Shinohara K
FAU - Sako, M
AU  - Sako M
FAU - Bessho, F
AU  - Bessho F
FAU - Yanagisawa, M
AU  - Yanagisawa M
FAU - Hayashi, Y
AU  - Hayashi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KMT2A protein, human)
RN  - 0 (MLLT6 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Artificial Gene Fusion
MH  - Base Sequence
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 17
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - Infant
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Molecular Sequence Data
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - Neoplasm Proteins/*genetics
MH  - *Proto-Oncogenes
MH  - RNA, Messenger/analysis
MH  - *Transcription Factors
MH  - *Translocation, Genetic
EDAT- 1999/09/15 00:00
MHDA- 1999/09/15 00:01
CRDT- 1999/09/15 00:00
PHST- 1999/09/15 00:00 [pubmed]
PHST- 1999/09/15 00:01 [medline]
PHST- 1999/09/15 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 Sep 1;59(17):4261-5.