PMID- 10485452
OWN - NLM
STAT- MEDLINE
DCOM- 19990930
LR  - 20091119
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 17
DP  - 1999 Sep 1
TI  - Expression of the steroid receptor RNA activator in human breast tumors.
PG  - 4190-3
AB  - The expression of the recently described steroid receptor RNA activator (SRA) was
      measured by semiquantitative reverse transcription-PCR within 27 independent
      breast tumors, spanning a wide spectrum of grade and estrogen receptor (ER) and
      progesterone receptor (PR) levels. Subgroup analysis showed that SRA expression
      was similar in ER+/PR+ (median = 65.5, n = 8) and in ER-/PR- (median = 94.6, n = 
      5) tumors. Interestingly, SRA expression in these two subgroups was significantly
      (Mann-Whitney rank-sum test, P < 0.05) lower than that observed in ER+/PR-
      (median = 156.4, n = 6) and ER-/PR+ (median = 144.8, n = 8) tumors. A variant
      form of SRA, presenting a deletion of 203 bp within the SRA core sequence, was
      also observed in breast tumor tissues. The relative expression of this new SRA
      isoform correlated with tumor grade (Spearman coefficient r = 0.53, n = 27, P =
      0.004). These data suggest that changes in the expression of SRA-related
      molecules occur during breast tumor progression.
FAU - Leygue, E
AU  - Leygue E
AD  - Department of Biochemistry, University of Manitoba, Faculty of Medicine,
      Winnipeg, Canada. eleygue@cc.umanitoba.ca
FAU - Dotzlaw, H
AU  - Dotzlaw H
FAU - Watson, P H
AU  - Watson PH
FAU - Murphy, L C
AU  - Murphy LC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - 0 (Receptors, Steroid)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (NCOA1 protein, human)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 1)
SB  - IM
MH  - Breast Neoplasms/chemistry/*genetics/pathology
MH  - Chromosomes, Human, Pair 5
MH  - Female
MH  - Histone Acetyltransferases
MH  - Humans
MH  - Nuclear Receptor Coactivator 1
MH  - RNA, Messenger/analysis
MH  - Receptors, Estrogen/analysis
MH  - Receptors, Progesterone/analysis
MH  - Receptors, Steroid/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Trans-Activators/*analysis
MH  - Transcription Factors/*analysis
EDAT- 1999/09/15 00:00
MHDA- 1999/09/15 00:01
CRDT- 1999/09/15 00:00
PHST- 1999/09/15 00:00 [pubmed]
PHST- 1999/09/15 00:01 [medline]
PHST- 1999/09/15 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 Sep 1;59(17):4190-3.