PMID- 10485450
OWN - NLM
STAT- MEDLINE
DCOM- 19990930
LR  - 20081121
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 17
DP  - 1999 Sep 1
TI  - Prostate-localized and androgen-regulated expression of the membrane-bound serine
      protease TMPRSS2.
PG  - 4180-4
AB  - Genes regulated by androgenic hormones are of critical importance for the normal 
      physiological function of the human prostate gland, and they contribute to the
      development and progression of prostate carcinoma. We used cDNA microarrays
      containing 1500 cDNAs to profile transcripts regulated by androgens in prostate
      cancer cells and identified the serine protease TMPRSS2 as a gene exhibiting
      increased expression upon exposure to androgens. The TMPRSS2 gene is located on
      chromosome 21 and contains four distinct domains, including a transmembrane
      region, indicating that it is expressed on the cell surface. Northern analysis
      demonstrated that TMPRSS2 is highly expressed in prostate epithelium relative to 
      other normal human tissues. In situ hybridization of normal and malignant
      prostate tissues localizes TMMPRSS2 expression to prostate basal cells and to
      prostate carcinoma. These results suggest that TMPRSS2 may play a role in
      prostate carcinogenesis and should be investigated as a diagnostic or therapeutic
      target for the management of prostate cancers.
FAU - Lin, B
AU  - Lin B
AD  - Department of Molecular Biotechnology, University of Washington, Seattle 98195,
      USA.
FAU - Ferguson, C
AU  - Ferguson C
FAU - White, J T
AU  - White JT
FAU - Wang, S
AU  - Wang S
FAU - Vessella, R
AU  - Vessella R
FAU - True, L D
AU  - True LD
FAU - Hood, L
AU  - Hood L
FAU - Nelson, P S
AU  - Nelson PS
LA  - eng
GR  - K08 CA75173-01A1/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Androgens)
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Androgens/*pharmacology
MH  - Cell Membrane/enzymology
MH  - DNA, Complementary/analysis
MH  - Gene Expression Regulation, Enzymologic/*drug effects
MH  - Humans
MH  - Male
MH  - Promoter Regions, Genetic
MH  - Prostate/*enzymology
MH  - RNA, Messenger/analysis
MH  - Serine Endopeptidases/*genetics
MH  - Tumor Cells, Cultured
EDAT- 1999/09/15 00:00
MHDA- 1999/09/15 00:01
CRDT- 1999/09/15 00:00
PHST- 1999/09/15 00:00 [pubmed]
PHST- 1999/09/15 00:01 [medline]
PHST- 1999/09/15 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 Sep 1;59(17):4180-4.