PMID- 10482244
OWN - NLM
STAT- MEDLINE
DCOM- 19990920
LR  - 20190822
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 23
IP  - 4
DP  - 1999 Aug
TI  - Calcium-stimulated adenylyl cyclase activity is critical for
      hippocampus-dependent long-term memory and late phase LTP.
PG  - 787-98
AB  - It is hypothesized that Ca2+ stimulation of calmodulin (CaM)-activated adenylyl
      cyclases (AC1 or AC8) generates cAMP signals critical for late phase LTP (L-LTP) 
      and long-term memory (LTM). However, mice lacking either AC1 or AC8 exhibit
      normal L-LTP and LTM. Here, we report that mice lacking both enzymes (DKO) do not
      exhibit L-LTP or LTM. To determine if these defects are due to a loss of cAMP
      increases in the hippocampus, DKO mice were unilaterally cannulated to deliver
      forskolin. Administration of forskolin to area CA1 before training restored
      normal LTM. We conclude that Ca2+-stimulated adenylyl cyclase activity is
      essential for L-LTP and LTM and that AC1 or AC8 can produce the necessary cAMP
      signal.
FAU - Wong, S T
AU  - Wong ST
AD  - Department of Pharmacology, University of Washington School of Medicine, Seattle 
      98195, USA.
FAU - Athos, J
AU  - Athos J
FAU - Figueroa, X A
AU  - Figueroa XA
FAU - Pineda, V V
AU  - Pineda VV
FAU - Schaefer, M L
AU  - Schaefer ML
FAU - Chavkin, C C
AU  - Chavkin CC
FAU - Muglia, L J
AU  - Muglia LJ
FAU - Storm, D R
AU  - Storm DR
LA  - eng
GR  - NS 20498/NS/NINDS NIH HHS/United States
GR  - NS 37056/NS/NINDS NIH HHS/United States
GR  - T32 GM07270/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Calmodulin)
RN  - 1F7A44V6OU (Colforsin)
RN  - EC 4.6.1.1 (Adenylyl Cyclases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adenylyl Cyclases/*metabolism
MH  - Animals
MH  - Avoidance Learning/physiology
MH  - Brain/drug effects/enzymology
MH  - Calcium/*physiology
MH  - Calmodulin/physiology
MH  - Colforsin/pharmacology
MH  - Cues
MH  - Electrophysiology
MH  - Fear/physiology/psychology
MH  - Hippocampus/drug effects/enzymology/*physiology
MH  - Immunohistochemistry
MH  - Long-Term Potentiation/drug effects/*physiology
MH  - Memory/drug effects/*physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Microscopy, Confocal
EDAT- 1999/09/11 00:00
MHDA- 1999/09/11 00:01
CRDT- 1999/09/11 00:00
PHST- 1999/09/11 00:00 [pubmed]
PHST- 1999/09/11 00:01 [medline]
PHST- 1999/09/11 00:00 [entrez]
AID - S0896-6273(01)80036-2 [pii]
AID - 10.1016/s0896-6273(01)80036-2 [doi]
PST - ppublish
SO  - Neuron. 1999 Aug;23(4):787-98. doi: 10.1016/s0896-6273(01)80036-2.