PMID- 10482239
OWN - NLM
STAT- MEDLINE
DCOM- 19990920
LR  - 20190822
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 23
IP  - 4
DP  - 1999 Aug
TI  - GFR alpha3, a component of the artemin receptor, is required for migration and
      survival of the superior cervical ganglion.
PG  - 725-36
AB  - GFR alpha3 is a component of the receptor for the neurotrophic factor artemin.
      The role of GFR alpha3 in nervous system development was examined by generating
      mice in which the Gfr alpha3 gene was disrupted. The Gfr alpha3-/- mice exhibited
      severe defects in the superior cervical ganglion (SCG), whereas other ganglia
      appeared normal. SCG precursor cells in the mutant embryos failed to migrate to
      the correct position, and they subsequently failed to innervate the target
      organs. In wild-type embryos, Gfr alpha3 was expressed in migrating SCG
      precursors, and artemin was expressed in and near the SCG. After birth, SCG
      neurons in the mutant mice underwent progressive cell death. These observations
      suggest that GFR alpha3-mediated signaling is required both for the rostral
      migration of SCG precursors and for the survival of mature SCG neurons.
FAU - Nishino, J
AU  - Nishino J
AD  - Division of Molecular Biology, Institute for Molecular and Cellular Biology,
      Osaka University, Japan.
FAU - Mochida, K
AU  - Mochida K
FAU - Ohfuji, Y
AU  - Ohfuji Y
FAU - Shimazaki, T
AU  - Shimazaki T
FAU - Meno, C
AU  - Meno C
FAU - Ohishi, S
AU  - Ohishi S
FAU - Matsuda, Y
AU  - Matsuda Y
FAU - Fujii, H
AU  - Fujii H
FAU - Saijoh, Y
AU  - Saijoh Y
FAU - Hamada, H
AU  - Hamada H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Artn protein, mouse)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-ret)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Ret protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Cell Death/physiology
MH  - Cell Movement/genetics/*physiology
MH  - Cell Survival/physiology
MH  - *Drosophila Proteins
MH  - Genotype
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Knockout
MH  - Nerve Growth Factors/*metabolism
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neurons/*physiology
MH  - Proto-Oncogene Proteins/genetics/*physiology
MH  - Proto-Oncogene Proteins c-ret
MH  - Receptor Protein-Tyrosine Kinases/genetics/*physiology
MH  - Receptors, Nerve Growth Factor/*genetics/*metabolism
MH  - Superior Cervical Ganglion/cytology/*embryology
EDAT- 1999/09/11 00:00
MHDA- 1999/09/11 00:01
CRDT- 1999/09/11 00:00
PHST- 1999/09/11 00:00 [pubmed]
PHST- 1999/09/11 00:01 [medline]
PHST- 1999/09/11 00:00 [entrez]
AID - S0896-6273(01)80031-3 [pii]
AID - 10.1016/s0896-6273(01)80031-3 [doi]
PST - ppublish
SO  - Neuron. 1999 Aug;23(4):725-36. doi: 10.1016/s0896-6273(01)80031-3.