PMID- 10482234
OWN - NLM
STAT- MEDLINE
DCOM- 19990920
LR  - 20190822
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 23
IP  - 4
DP  - 1999 Aug
TI  - Requirement for the homeobox gene Hb9 in the consolidation of motor neuron
      identity.
PG  - 659-74
AB  - The homeobox gene Hb9, like its close relative MNR2, is expressed selectively by 
      motor neurons (MNs) in the developing vertebrate CNS. In embryonic chick spinal
      cord, the ectopic expression of MNR2 or Hb9 is sufficient to trigger MN
      differentiation and to repress the differentiation of an adjacent population of
      V2 interneurons. Here, we provide genetic evidence that Hb9 has an essential role
      in MN differentiation. In mice lacking Hb9 function, MNs are generated on
      schedule and in normal numbers but transiently acquire molecular features of V2
      interneurons. The aberrant specification of MN identity is associated with
      defects in the migration of MNs, the emergence of the subtype identities of MNs, 
      and the projection of motor axons. These findings show that HB9 has an essential 
      function in consolidating the identity of postmitotic MNs.
FAU - Arber, S
AU  - Arber S
AD  - Howard Hughes Medical Institute, Department of Biochemistry and Molecular
      Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, 
      New York 10032, USA.
FAU - Han, B
AU  - Han B
FAU - Mendelsohn, M
AU  - Mendelsohn M
FAU - Smith, M
AU  - Smith M
FAU - Jessell, T M
AU  - Jessell TM
FAU - Sockanathan, S
AU  - Sockanathan S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Homeodomain Proteins)
RN  - 0 (LIM-Homeodomain Proteins)
RN  - 0 (Lhx3 protein)
RN  - 0 (MNR2 protein, vertebrate)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Transcription Factors)
RN  - 140115-73-7 (Hb9 protein, mouse)
SB  - IM
CIN - Neuron. 1999 Aug;23(4):626-7. PMID: 10482225
MH  - Animals
MH  - Axons/physiology
MH  - Cell Differentiation/physiology
MH  - Cell Movement/genetics/physiology
MH  - Chick Embryo
MH  - Gene Expression Regulation, Developmental/*genetics/physiology
MH  - Genes, Homeobox/*genetics
MH  - Homeodomain Proteins/biosynthesis/*genetics
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Interneurons/physiology
MH  - LIM-Homeodomain Proteins
MH  - Mice
MH  - Mice, Transgenic
MH  - Motor Neurons/*physiology
MH  - Muscle, Skeletal/embryology/innervation
MH  - Nerve Tissue Proteins/biosynthesis
MH  - Spinal Cord/cytology/*embryology/physiology
MH  - Transcription Factors/*genetics
MH  - Transgenes
EDAT- 1999/09/11 00:00
MHDA- 1999/09/11 00:01
CRDT- 1999/09/11 00:00
PHST- 1999/09/11 00:00 [pubmed]
PHST- 1999/09/11 00:01 [medline]
PHST- 1999/09/11 00:00 [entrez]
AID - S0896-6273(01)80026-X [pii]
AID - 10.1016/s0896-6273(01)80026-x [doi]
PST - ppublish
SO  - Neuron. 1999 Aug;23(4):659-74. doi: 10.1016/s0896-6273(01)80026-x.