PMID- 10481065
OWN - NLM
STAT- MEDLINE
DCOM- 19991013
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 458
IP  - 2
DP  - 1999 Sep 17
TI  - Structure of the human VIPR2 gene for vasoactive intestinal peptide receptor type
      2.
PG  - 197-203
AB  - The VPAC(2) (vasoactive intestinal peptide (VIP)(2)) receptor is a
      seven-transmembrane spanning G protein-coupled receptor which responds similarly 
      to VIP and pituitary adenylate cyclase activating polypeptide (PACAP) in
      stimulating cAMP production. Recently, we reported the localisation of the human 
      VPAC(2) receptor gene (VIPR2) to chromosome 7q36.3 (Mackay, M. et al. (1996)
      Genomics 37, 345-353). Here, we describe the characterisation of the VIPR2 gene
      structure and promoter region. The VIPR2 gene is encoded by 13 exons, the
      initiator codon of the 438 amino acid open reading frame is located in exon 1 and
      the termination signal and a poly-adenylation signal sequence are located in exon
      13. The 5' untranslated region extends 187 bp upstream of the initiator codon and
      is extremely GC-rich (80%). The poly-adenylation signal is located 2416 bp
      downstream of the stop codon. Intron sizes range from 68 bp (intron 11) to 45 kb 
      (intron 4) and the human gene spans 117 kb.
FAU - Lutz, E M
AU  - Lutz EM
AD  - MRC Brain Metabolism Unit, University Department of Neuroscience, Edinburgh, UK. 
      elutz@srv1.bmu.mrc.ac.uk
FAU - Shen, S
AU  - Shen S
FAU - Mackay, M
AU  - Mackay M
FAU - West, K
AU  - West K
FAU - Harmar, A J
AU  - Harmar AJ
LA  - eng
SI  - GENBANK/X95097
SI  - GENBANK/Y18423
SI  - GENBANK/Y18424
SI  - GENBANK/Y18425
SI  - GENBANK/Y18426
SI  - GENBANK/Y18427
SI  - GENBANK/Y18428
SI  - GENBANK/Y18429
SI  - GENBANK/Y18430
SI  - GENBANK/Y18431
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (5' Untranslated Regions)
RN  - 0 (DNA, Complementary)
RN  - 0 (Receptors, Vasoactive Intestinal Peptide)
RN  - 0 (Receptors, Vasoactive Intestinal Peptide, Type II)
RN  - 0 (Transcription Factors)
RN  - 0 (VIPR2 protein, human)
RN  - 5Z93L87A1R (Guanine)
RN  - 8J337D1HZY (Cytosine)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - 5' Untranslated Regions/genetics
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Binding Sites/genetics
MH  - Chromosomes, Artificial, Yeast/genetics
MH  - Chromosomes, Human, Pair 7
MH  - Cloning, Molecular
MH  - Consensus Sequence
MH  - Cytosine
MH  - DNA, Complementary/chemistry/isolation & purification
MH  - Exons
MH  - GTP-Binding Proteins/metabolism
MH  - Guanine
MH  - Humans
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic/genetics
MH  - Receptors, Vasoactive Intestinal Peptide/*chemistry/*genetics/isolation &
      purification
MH  - Receptors, Vasoactive Intestinal Peptide, Type II
MH  - Transcription Factors/genetics/metabolism
EDAT- 1999/09/11 00:00
MHDA- 1999/09/11 00:01
CRDT- 1999/09/11 00:00
PHST- 1999/09/11 00:00 [pubmed]
PHST- 1999/09/11 00:01 [medline]
PHST- 1999/09/11 00:00 [entrez]
AID - S0014-5793(99)01135-7 [pii]
AID - 10.1016/s0014-5793(99)01135-7 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Sep 17;458(2):197-203. doi: 10.1016/s0014-5793(99)01135-7.