PMID- 10480904
OWN - NLM
STAT- MEDLINE
DCOM- 19991013
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 38
DP  - 1999 Sep 17
TI  - A candidate target for G protein action in brain.
PG  - 26931-8
AB  - An effector candidate for G protein action, GRIN1, was identified by screening a 
      cDNA expression library with phosphorylated GTPgammaS-G(z)alpha as a probe. GRIN1
      is a novel protein without substantial homology to known protein domains. It is
      expressed largely in brain and binds specifically to activated G(z)alpha,
      G(o)alpha, and G(i)alpha through its carboxyl-terminal region. The protein
      KIAA0514 (GRIN2) is homologous to GRIN1 at its carboxyl terminus and also binds
      to activated G(o)alpha. Both GRIN1 and G(o)alpha are membrane-bound proteins that
      are enriched in the growth cones of neurites. Coexpression of GRIN1 or GRIN2 with
      activated G(o)alpha causes formation of a network of fine processes in Neuro2a
      cells, suggesting that these pathways may function downstream of G(o)alpha to
      control growth of neurites.
FAU - Chen, L T
AU  - Chen LT
AD  - Department of Pharmacology, University of Texas Southwestern Medical Center,
      Dallas, Texas 75235-9041, USA.
FAU - Gilman, A G
AU  - Gilman AG
FAU - Kozasa, T
AU  - Kozasa T
LA  - eng
SI  - GENBANK/AF146569
GR  - GM34497/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Gprin1 protein, mouse)
RN  - 0 (Gprin2 protein, mouse)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 37589-80-3 (Guanosine 5'-O-(3-Thiotriphosphate))
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/*metabolism
MH  - Carrier Proteins/*metabolism
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - GTP-Binding Proteins/*physiology
MH  - Guanosine 5'-O-(3-Thiotriphosphate)/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Molecular Weight
MH  - Nerve Tissue Proteins
MH  - Receptors, N-Methyl-D-Aspartate
MH  - Sequence Alignment
EDAT- 1999/09/10 00:00
MHDA- 1999/09/10 00:01
CRDT- 1999/09/10 00:00
PHST- 1999/09/10 00:00 [pubmed]
PHST- 1999/09/10 00:01 [medline]
PHST- 1999/09/10 00:00 [entrez]
AID - 10.1074/jbc.274.38.26931 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Sep 17;274(38):26931-8. doi: 10.1074/jbc.274.38.26931.