PMID- 10479690
OWN - NLM
STAT- MEDLINE
DCOM- 19991004
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 18
DP  - 1999 Sep 15
TI  - The medial ganglionic eminence gives rise to a population of early neurons in the
      developing cerebral cortex.
PG  - 7881-8
AB  - During development of the neocortex, the marginal zone (layer I) and the subplate
      (layer VII) are the first layers to form from a primordial plexiform neoropil.
      The cortical plate (layers II-VI) is subsequently established between these
      superficial and deep components of the primordial plexiform neuropil. Neurons in 
      the early zones are thought to play important roles in the formation of the
      cortex: the Cajal-Retzius cells of the marginal zone are instrumental in neuronal
      migration and laminar formation, and cells of the subplate are involved in the
      formation of cortical connections. Using the fluorescent tracer
      1,1'-dioctodecyl-3,3,3', 3'-tetramethylindocarbocyanine (DiI), we have shown here
      that a substantial proportion of neurons of the marginal zone, including cells
      with features of Cajal-Retzius cells, and of the subplate and lower intermediate 
      zone are not born in the ventricular neuroepithelium but instead originate in the
      medial ganglionic eminence (MGE), the pallidal primordium. These neurons follow a
      tangential migratory route to their positions in the developing cortex. They
      express the neurotransmitter GABA but seem to lack the calcium binding protein
      calretinin; some migrating cells found in the marginal zone express reelin. In
      addition, migrating cells express the LIM-homeobox gene Lhx6, a characteristic
      marker of the MGE. It is suggested that this gene uniquely or in combination with
      other transcription factors may be involved in the decision of MGE cells to
      differentiate in situ or migrate to the neocortex.
FAU - Lavdas, A A
AU  - Lavdas AA
AD  - Department of Anatomy and Developmental Biology, University College London,
      London WC1E 6BT, United Kingdom.
FAU - Grigoriou, M
AU  - Grigoriou M
FAU - Pachnis, V
AU  - Pachnis V
FAU - Parnavelas, J G
AU  - Parnavelas JG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for
      Neuroscience
JID - 8102140
RN  - 0 (Carbocyanines)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Reelin Protein)
RN  - 0 (Reln protein, rat)
RN  - 40957-95-7 (3,3'-dioctadecylindocarbocyanine)
SB  - IM
MH  - Animals
MH  - Brain/cytology/*embryology
MH  - Carbocyanines
MH  - Cell Movement
MH  - Cerebral Cortex/cytology/*embryology
MH  - *Embryonic and Fetal Development
MH  - Fluorescent Dyes
MH  - Gene Expression Regulation, Developmental
MH  - Homeodomain Proteins/genetics
MH  - Morphogenesis
MH  - *Nerve Tissue Proteins
MH  - Neurons/*cytology
MH  - Organ Culture Techniques
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reelin Protein
MH  - Zinc Fingers
PMC - PMC6782477
EDAT- 1999/09/10 00:00
MHDA- 1999/09/10 00:01
CRDT- 1999/09/10 00:00
PHST- 1999/09/10 00:00 [pubmed]
PHST- 1999/09/10 00:01 [medline]
PHST- 1999/09/10 00:00 [entrez]
PST - ppublish
SO  - J Neurosci. 1999 Sep 15;19(18):7881-8.